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    modE DNA-binding transcriptional dual regulator ModE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945366, updated on 3-Dec-2024

    Summary

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    Official Symbol
    modE
    Official Full Name
    DNA-binding transcriptional dual regulator ModE
    Primary source
    ECOCYC:G6395
    Locus tag
    b0761
    See related
    ASAP:ABE-0002585
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    chlD; ECK0750; modR
    Summary
    ModE mutants are unable to reduce selenate. [More information is available at EcoGene: EG13227].
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    Genomic context

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    Sequence:
    NC_000913.3 (793856..794644, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-glucose 4-epimerase Neighboring gene ABC family protein ModF Neighboring gene multidrug efflux pump accessory protein AcrZ Neighboring gene molybdate ABC transporter periplasmic binding protein Neighboring gene molybdate ABC transporter membrane subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Anaerobic regulation of the Escherichia coli dmsABC operon requires the molybdate-responsive regulator ModE. McNicholas PM, et al. Mol Microbiol, 1998 Jan. PMID 9466267
    2. Functional dissection of the molybdate-responsive transcription regulator, ModE, from Escherichia coli. McNicholas PM, et al. J Bacteriol, 1998 Sep. PMID 9721306, Free PMC Article
    3. Sensing of remote oxyanion binding at the DNA binding domain of the molybdate-dependent transcriptional regulator, ModE. Boxer DH, et al. Org Biomol Chem, 2004 Oct 7. PMID 15455157
    4. A DNA element recognised by the molybdenum-responsive transcription factor ModE is conserved in Proteobacteria, green sulphur bacteria and Archaea. Studholme DJ, et al. BMC Microbiol, 2003 Dec 2. PMID 14641908, Free PMC Article
    5. Oxyanion binding alters conformation and quaternary structure of the c-terminal domain of the transcriptional regulator mode. Implications for molybdate-dependent regulation, signaling, storage, and transport. Gourley DG, et al. J Biol Chem, 2001 Jun 8. PMID 11259434

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molybdenum ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in molybdate ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ModE complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator ModE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      793856..794644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415282.1 DNA-binding transcriptional dual regulator ModE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415282.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1IZI1
      Conserved Domains (1) summary
      PRK10676
      Location:1 → 262
      PRK10676; DNA-binding transcriptional regulator ModE; Provisional
    Nucleotide Protein
    Heading Accession and Version

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