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    wcaK colanic acid biosynthesis pyruvyl transferase WcaK [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946569, updated on 3-Dec-2024

    Summary

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    Official Symbol
    wcaK
    Official Full Name
    colanic acid biosynthesis pyruvyl transferase WcaK
    Primary source
    ECOCYC:G7096
    Locus tag
    b2045
    See related
    ASAP:ABE-0006780
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2039
    Summary
    Overexpression causes a decrease in the amount of biofilm formed. [More information is available at EcoGene: EG13577]. WcaK may be involved in colanic acid synthesis based on sequence and its presence in a putative colanic acid synthesis operon , though there is no evidence suggesting a function for this protein. [More information is available at EcoCyc: G7096].
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    Genomic context

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    Sequence:
    NC_000913.3 (2117124..2118404, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UTP:glucose-1-phosphate uridylyltransferase, low activity Neighboring gene putative colanic acid biosynthesis protein WcaM Neighboring gene putative colanic acid biosynthesis glycosyl transferase WcaL Neighboring gene colanic acid repeat unit flippase Neighboring gene UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Group II intron protein localization and insertion sites are affected by polyphosphate. Zhao J, et al. PLoS Biol, 2008 Jun 24. PMID 18593213, Free PMC Article
    2. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Whitfield C. Annu Rev Biochem, 2006. PMID 16756484
    3. Development of a biofilm production-deficient Escherichia coli strain as a host for biotechnological applications. Sung BH, et al. Appl Environ Microbiol, 2006 May. PMID 16672475, Free PMC Article
    4. Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli. Hagiwara D, et al. J Bacteriol, 2003 Oct. PMID 13129944, Free PMC Article
    5. Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in Escherichia coli. Reid AJ, et al. Biochemistry, 2021 Jul 13. PMID 34159784, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within colanic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in slime layer polysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    colanic acid biosynthesis pyruvyl transferase WcaK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2117124..2118404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416549.1 colanic acid biosynthesis pyruvyl transferase WcaK [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416549.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376S9A4, A0A8H9XMI0
      Conserved Domains (1) summary
      TIGR04006
      Location:1 → 426
      wcaK; colanic acid biosynthesis pyruvyl transferase WcaK
    Nucleotide Protein
    Heading Accession and Version

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