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    glk glucokinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946858, updated on 3-Dec-2024

    Summary

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    Official Symbol
    glk
    Official Full Name
    glucokinase
    Primary source
    ECOCYC:EG12957
    Locus tag
    b2388
    See related
    ASAP:ABE-0007875
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2384
    Summary
    The cytoplasmic glucokinase is not required for growth on glucose as the carbon source, because glucose is phosphorylated during transport by the PTS system. [More information is available at EcoCyc: EG12957].
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    Genomic context

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    Sequence:
    NC_000913.3 (2508461..2509426, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative PTS enzyme IIC component FryC Neighboring gene putative PTS enzyme IIB component FryB Neighboring gene putative transport protein YfeO Neighboring gene DUF2502 domain-containing protein YpeC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA microarray detection of metabolic responses to protein overproduction in Escherichia coli. Oh MK, et al. Metab Eng, 2000 Jul. PMID 11056062
    2. PREFERENTIAL GALACTOSE UTILIZATION IN A MUTANT STRAIN OF E. COLI. ASENSIO C, et al. Arch Biochem Biophys, 1963 Dec. PMID 14103281
    3. THE UTILIZATION OF GLUCOSE 6-PHOSPHATE BY GLUCOKINASELESS AND WILD-TYPE STRAINS OF ESCHERICHIA COLI. FRAENKEL DG, et al. Proc Natl Acad Sci U S A, 1964 Nov. PMID 14231443, Free PMC Article
    4. Utilization and phosphorylation of sugars by Escherichia coli. ASENSIO C, et al. Rev Esp Fisiol, 1958 Dec. PMID 13658662
    5. Crystal structures of Escherichia coli ATP-dependent glucokinase and its complex with glucose. Lunin VV, et al. J Bacteriol, 2004 Oct. PMID 15466045, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-glucose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose 6-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycolytic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucokinase
    NP_416889.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2508461..2509426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416889.1 glucokinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416889.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FPW9
      Conserved Domains (1) summary
      PRK00292
      Location:2 → 316
      glk; glucokinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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