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    gcvA DNA-binding transcriptional dual regulator GcvA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947278, updated on 17-Dec-2024

    Summary

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    Official Symbol
    gcvA
    Official Full Name
    DNA-binding transcriptional dual regulator GcvA
    Primary source
    ECOCYC:EG11795
    Locus tag
    b2808
    See related
    ASAP:ABE-0009202
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2803
    Summary
    Glycine co-activator binds to GcvR and disrupts GcvA-GcvR interaction. [More information is available at EcoGene: EG11795]. "Glycine cleavage A," GcvA, is a repressor of the glycine cleavage enzyme system, which is a secondary pathway for production of C1 units . [More information is available at EcoCyc: EG11795].
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    Genomic context

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    Sequence:
    NC_000913.3 (2941650..2942567, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator FucR Neighboring gene 23S rRNA 2'-O-ribose C2498 methyltransferase Neighboring gene DUF423 domain-containing inner membrane protein YgdD Neighboring gene ncRNA Neighboring gene DUF903 domain-containing lipoprotein YgdI

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the genes in multicopy plasmids affecting ompC and ompF expression in Escherichia coli. Jin T, et al. FEMS Microbiol Lett, 1995 Nov 15. PMID 8522138
    2. Genetic analysis of the GcvA binding site in the gcvA control region. Jourdan AD, et al. Microbiology (Reading), 1999 Aug. PMID 10463182
    3. DNA binding sites of the LysR-type regulator GcvA in the gcv and gcvA control regions of Escherichia coli. Wilson RL, et al. J Bacteriol, 1995 Sep. PMID 7665470, Free PMC Article
    4. Roles of the GcvA and PurR proteins in negative regulation of the Escherichia coli glycine cleavage enzyme system. Wilson RL, et al. J Bacteriol, 1993 Aug. PMID 8349552, Free PMC Article
    5. Mutational analysis of the transcriptional regulator GcvA: amino acids important for activation, repression, and DNA binding. Jourdan AD, et al. J Bacteriol, 1998 Sep. PMID 9733689, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator GcvA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2941650..2942567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417288.1 DNA-binding transcriptional dual regulator GcvA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417288.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376NUE5
      Conserved Domains (1) summary
      PRK11139
      Location:1 → 297
      PRK11139; DNA-binding transcriptional activator GcvA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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