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    mlaF intermembrane phospholipid transport system, ATP binding subunit MlaF [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947729, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mlaF
    Official Full Name
    intermembrane phospholipid transport system, ATP binding subunit MlaF
    Primary source
    ECOCYC:EG12801
    Locus tag
    b3195
    See related
    ASAP:ABE-0010498
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3184; yrbF
    Summary
    YrbF is the ATP-binding component of a predicted ABC superfamily toluene efflux transporter. [More information is available at EcoCyc: EG12801].
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    Genomic context

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    Sequence:
    NC_000913.3 (3339256..3340065, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene intermembrane phospholipid transport system, substrate binding protein MlaD Neighboring gene intermembrane phospholipid transport system, integral membrane subunit MlaE Neighboring gene putative transport protein YrbG Neighboring gene D-arabinose 5-phosphate isomerase KdsD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation. Kolich LR, et al. Elife, 2020 Jun 30. PMID 32602838, Free PMC Article
    2. Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Tang X, et al. Nat Struct Mol Biol, 2021 Jan. PMID 33199922
    3. Unanticipated functional diversity among the TatA-type components of the Tat protein translocase. Eimer E, et al. Sci Rep, 2018 Jan 22. PMID 29358647, Free PMC Article
    4. Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry. Thong S, et al. Elife, 2016 Aug 16. PMID 27529189, Free PMC Article
    5. Identification of two Shigella flexneri chromosomal loci involved in intercellular spreading. Hong M, et al. Infect Immun, 1998 Oct. PMID 9746567, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phospholipid transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intermembrane phospholipid transfer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipid transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of phospholipid-translocating ATPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intermembrane phospholipid transport system, ATP binding subunit MlaF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3339256..3340065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417662.1 intermembrane phospholipid transport system, ATP binding subunit MlaF [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417662.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6PHR2
      Conserved Domains (1) summary
      PRK11831
      Location:2 → 269
      PRK11831; phospholipid ABC transporter ATP-binding protein MlaF
    Nucleotide Protein
    Heading Accession and Version

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