sipa-1 Rap-GAP domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sipa-1
Official Full Name: Rap-GAP domain-containing protein
Primary source: WormBase:WBGene00012100
Locus tag: CELE_T27F2.2
See related: AllianceGenome:WB:WBGene00012100
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in cataract 45. Orthologous to several human genes including SIPA1L1 (signal induced proliferation associated 1 like 1); SIPA1L2 (signal induced proliferation associated 1 like 2); and SIPA1L3 (signal induced proliferation associated 1 like 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sipa-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 12

Sequence:: Chromosome: V; NC_003283.11 (11631424..11637291, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T27F2.2 (e-PCR)
- UniSTS:306546

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Rap-GAP domain-containing protein

NP_001256343.1

Partially confirmed by transcript evidence

NP_001256344.1

Confirmed by transcript evidence

NP_001256345.1

Confirmed by transcript evidence

NP_001256346.1

Confirmed by transcript evidence

NP_001256347.1

Confirmed by transcript evidence

NP_001263863.1

Confirmed by transcript evidence

NP_001360526.1

Partially confirmed by transcript evidence

NP_001360527.1

Partially confirmed by transcript evidence

NP_001360528.1

Partially confirmed by transcript evidence

NP_001360529.1

Confirmed by transcript evidence

NP_001360530.1

Partially confirmed by transcript evidence

NP_001360531.1

Confirmed by transcript evidence

NP_001360532.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11631424..11637291 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373118.3 → NP_001360529.1 Rap-GAP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WX54

Conserved Domains (3) summary

cd00992
Location:720 → 794

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:393 → 573

Rap_GAP; Rap/ran-GAP

pfam18595
Location:907 → 965

DHR10; Designed helical repeat protein 10 domain
NM_001373116.3 → NP_001360532.1 Rap-GAP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WYD5

Conserved Domains (3) summary

cd00992
Location:711 → 785

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:384 → 564

Rap_GAP; Rap/ran-GAP

pfam18595
Location:929 → 987

DHR10; Designed helical repeat protein 10 domain
NM_001269417.2 → NP_001256346.1 Rap-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256346.1

Status: REVIEWED

UniProtKB/TrEMBL

H2L2C1

Conserved Domains (3) summary

cd00992
Location:720 → 794

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:393 → 573

Rap_GAP; Rap/ran-GAP

cl23720
Location:812 → 943

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001269416.2 → NP_001256345.1 Rap-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256345.1

Status: REVIEWED

UniProtKB/TrEMBL

H2L2C3

Conserved Domains (3) summary

cd00992
Location:720 → 794

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:393 → 573

Rap_GAP; Rap/ran-GAP

pfam18595
Location:905 → 963

DHR10; Designed helical repeat protein 10 domain
NM_001373119.1 → NP_001360531.1 Rap-GAP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WXF2

Conserved Domains (3) summary

cd00992
Location:720 → 794

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:393 → 573

Rap_GAP; Rap/ran-GAP

pfam18595
Location:938 → 996

DHR10; Designed helical repeat protein 10 domain
NM_001269418.3 → NP_001256347.1 Rap-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256347.1

Status: REVIEWED

UniProtKB/TrEMBL

H2L2C2

Conserved Domains (3) summary

cd00992
Location:720 → 794

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:393 → 573

Rap_GAP; Rap/ran-GAP

pfam18595
Location:939 → 997

DHR10; Designed helical repeat protein 10 domain
NM_001373115.3 → NP_001360527.1 Rap-GAP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WXR6

Conserved Domains (3) summary

cd00992
Location:711 → 785

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:384 → 564

Rap_GAP; Rap/ran-GAP

pfam18595
Location:927 → 985

DHR10; Designed helical repeat protein 10 domain
NM_001276934.4 → NP_001263863.1 Rap-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263863.1

Status: REVIEWED

UniProtKB/TrEMBL

L8E7Y6

Conserved Domains (3) summary

cd00992
Location:720 → 794

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:393 → 573

Rap_GAP; Rap/ran-GAP

pfam18595
Location:936 → 994

DHR10; Designed helical repeat protein 10 domain
NM_001269415.2 → NP_001256344.1 Rap-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256344.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBY5

Conserved Domains (3) summary

cd00992
Location:720 → 794

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:393 → 573

Rap_GAP; Rap/ran-GAP

pfam18595
Location:937 → 995

DHR10; Designed helical repeat protein 10 domain
NM_001269414.4 → NP_001256343.1 Rap-GAP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256343.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBQ9

Conserved Domains (2) summary

cd00992
Location:711 → 785

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:384 → 564

Rap_GAP; Rap/ran-GAP
NM_001373112.2 → NP_001360528.1 Rap-GAP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WTR7

Conserved Domains (3) summary

cd00992
Location:711 → 785

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:384 → 564

Rap_GAP; Rap/ran-GAP

cl23720
Location:803 → 934

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001373113.2 → NP_001360526.1 Rap-GAP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WWS2

Conserved Domains (3) summary

cd00992
Location:711 → 785

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:384 → 564

Rap_GAP; Rap/ran-GAP

pfam18595
Location:896 → 954

DHR10; Designed helical repeat protein 10 domain
NM_001373114.2 → NP_001360530.1 Rap-GAP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WWL8

Conserved Domains (3) summary

cd00992
Location:711 → 785

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:384 → 564

Rap_GAP; Rap/ran-GAP

pfam18595
Location:898 → 956

DHR10; Designed helical repeat protein 10 domain