mei-P26 meiotic P26 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mei-P26provided by FlyBase
Official Full Name: meiotic P26provided by FlyBase
Primary source: FLYBASE:FBgn0026206
Locus tag: Dmel_CG12218
See related: AllianceGenome:FB:FBgn0026206
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AF145661; BcDNA:GH10646; CG12218; Dmel\CG12218; mei-p26; Mei-P26; MEI-P26; meiP26
Summary: Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in germ cell development; meiotic cell cycle; and spermatogenesis. Predicted to be located in cytoplasm. Is expressed in several structures, including germarium; germline cell; larval nervous system; ovary; and pole plasm. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia and skin cancer. Orthologous to human PML (PML nuclear body scaffold). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 8C15-8C17; 1-26 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (9163255..9189309)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (9057288..9083342)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation.
Title: Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation.
Wh is a regulator of Mei-p26 in Drosophila germ cells
Title: WD40 protein Wuho controls germline homeostasis via TRIM-NHL tumor suppressor Mei-p26 in Drosophila.
Mei-P26 mediates tissue-specific responses to Brat and dMyc activities.
Title: Mei-P26 mediates tissue-specific responses to the Brat tumor suppressor and the dMyc proto-oncogene in Drosophila.
Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early germline stem cell development, suggesting that this protein helps to repress the translation of nanos mRNA.
Title: Mei-p26 cooperates with Bam, Bgcn and Sxl to promote early germline development in the Drosophila ovary.
Thus, germ cells progress through distinct, sequential regulatory states, from Mei-P26 on/Bam off to Bam on/Mei-P26 off.
Title: A self-limiting switch based on translational control regulates the transition from proliferation to differentiation in an adult stem cell lineage.
Mei-P26 has distinct functions in the ovary and participates in regulating the fates of both germline stem cells and their differentiating daughters.
Title: Mei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signaling.
miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing
Title: The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing.
Vas promotes germ cell differentiation by directly activating mei-P26 translation in early-stage committed cells
Title: Vasa promotes Drosophila germline stem cell differentiation by activating mei-P26 translation by directly interacting with a (U)-rich motif in its 3' UTR.
the Trim-NHL protein Mei-P26 restricts growth and proliferation in the ovarian stem cell lineage
Title: Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: meiotic P26

Names: CG12218-PA; CG12218-PB; CG12218-PC; CG12218-PD; CG12218-PE; CG12218-PF; mei-P26-PA; mei-P26-PB; mei-P26-PC; mei-P26-PD; mei-P26-PE; mei-P26-PF; meiotic-P26

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

9163255..9189309

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272448.2 → NP_001259377.1 meiotic P26, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259377.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PH32, Q9Y111

Conserved Domains (3) summary

smart00502
Location:369 → 494

BBC; B-Box C-terminal domain

cd00021
Location:321 → 360

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd14959
Location:930 → 1203

NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
NM_001369966.1 → NP_001356936.1 meiotic P26, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4D6K5H4, Q9Y111

Conserved Domains (4) summary

smart00502
Location:369 → 494

BBC; B-Box C-terminal domain

cd00021
Location:321 → 360

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd14959
Location:913 → 1186

NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins

cl17238
Location:158 → 230

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_143765.4 → NP_652022.1 meiotic P26, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_652022.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W378, Q9Y111

Related

FBpp0071238

Conserved Domains (3) summary

smart00502
Location:369 → 494

BBC; B-Box C-terminal domain

cd00021
Location:321 → 360

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd14959
Location:913 → 1186

NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
NM_001272449.1 → NP_001259378.1 meiotic P26, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259378.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W378, Q9Y111

Conserved Domains (3) summary

smart00502
Location:369 → 494

BBC; B-Box C-terminal domain

cd00021
Location:321 → 360

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd14959
Location:913 → 1186

NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
NM_001272447.2 → NP_001259376.1 meiotic P26, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259376.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W378, Q9Y111

Conserved Domains (3) summary

smart00502
Location:369 → 494

BBC; B-Box C-terminal domain

cd00021
Location:321 → 360

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd14959
Location:913 → 1186

NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
NM_001298110.1 → NP_001285039.1 meiotic P26, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285039.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PH32, Q9Y111

Conserved Domains (3) summary

smart00502
Location:369 → 494

BBC; B-Box C-terminal domain

cd00021
Location:321 → 360

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd14959
Location:930 → 1203

NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins