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    SLC2A12 solute carrier family 2 member 12 [ Homo sapiens (human) ]

    Gene ID: 154091, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SLC2A12provided by HGNC
    Official Full Name
    solute carrier family 2 member 12provided by HGNC
    Primary source
    HGNC:HGNC:18067
    See related
    Ensembl:ENSG00000146411 MIM:610372; AllianceGenome:HGNC:18067
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLUT8; GLUT12
    Summary
    SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in prostate (RPKM 9.5), endometrium (RPKM 4.6) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC2A12 in Genome Data Viewer
    Location:
    6q23.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (133987581..134052624, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (135175590..135240550, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (134308719..134373762, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:134209799-134210712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:134211964-134212728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:134213614-134214222 Neighboring gene transcription factor 21 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17555 Neighboring gene umcharacterized LOC128092253 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90026 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25081 Neighboring gene TATA-box binding protein like 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90037 Neighboring gene epithelial splicing regulatory protein 1 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:134381498-134382162 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:134382163-134382827 Neighboring gene uncharacterized LOC124901404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17556 Neighboring gene high mobility group AT-hook 1 pseudogene 7 Neighboring gene RNA, 7SL, cytoplasmic 408, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel glucose transporter-like protein-GLUT-12. Rogers S, et al. Am J Physiol Endocrinol Metab, 2002 Mar. PMID 11832379
    2. Glucose transporter GLUT12-functional characterization in Xenopus laevis oocytes. Rogers S, et al. Biochem Biophys Res Commun, 2003 Aug 29. PMID 12914765
    3. Alternative Splicing and Cleavage of GLUT8. Alexander CM, et al. Mol Cell Biol, 2020 Dec 21. PMID 33077497, Free PMC Article
    4. Hypoxia promotes the growth and metastasis of ovarian cancer cells by suppressing ferroptosis via upregulating SLC2A12. Li M, et al. Exp Cell Res, 2023 Dec 15. PMID 37940066
    5. Expression of the glucose transporter GLUT12 in Alzheimer's disease patients. Pujol-Gimenez J, et al. J Alzheimers Dis, 2014. PMID 24820014

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypoxia promotes the growth and metastasis of ovarian cancer cells by suppressing ferroptosis via upregulating SLC2A12.
      Title: Hypoxia promotes the growth and metastasis of ovarian cancer cells by suppressing ferroptosis via upregulating SLC2A12.
    2. Inhibition of androgen receptor enhanced the anticancer effects of everolimus through targeting glucose transporter 12.
      Title: Inhibition of androgen receptor enhanced the anticancer effects of everolimus through targeting glucose transporter 12.
    3. Epithelial mesenchymal transition regulator TWIST1 transcription factor stimulates glucose uptake through upregulation of GLUT1, GLUT3, and GLUT12 in vitro.
      Title: Epithelial mesenchymal transition regulator TWIST1 transcription factor stimulates glucose uptake through upregulation of GLUT1, GLUT3, and GLUT12 in vitro.
    4. Let-7a-5p inhibits triple-negative breast tumor growth and metastasis through GLUT12-mediated warburg effect.
      Title: Let-7a-5p inhibits triple-negative breast tumor growth and metastasis through GLUT12-mediated warburg effect.
    5. Alternative Splicing and Cleavage of GLUT8.
      Title: Alternative Splicing and Cleavage of GLUT8.
    6. We hypothesize that GLUT12 would contribute to modulate sugar absorption in physiological and pathophysiological situations such as obesity.
      Title: GLUT12 and adipose tissue: Expression, regulation and its relation with obesity in mice.
    7. GLUT12 rapid translocation to the enterocytes apical membrane in response to glucose and insulin could be related to GLUT12 participation in sugar absorption during postprandial periods. In the pathological condition of obesity, in which insulin sensitivity is reduced, the contribution of GLUT12 to sugar absorption would be affected.
      Title: GLUT12 expression and regulation in murine small intestine and human Caco-2 cells.
    8. GLUT12-knockdown completely abrogated high glucose-induced migration, indicating that GLUT12 functionally participates in sensing high glucose concentrations.
      Title: Potential Roles of GLUT12 for Glucose Sensing and Cellular Migration in MCF-7 Human Breast Cancer Cells Under High Glucose Conditions.
    9. GLUT12 is a versatile transporter: it transports a wide diversity of hexoses, it can work as a Na+ or H+/glucose symporter, and it shows electrogenic properties.
      Title: Functional characterization of the human facilitative glucose transporter 12 (GLUT12) by electrophysiological methods.
    10. findings show the level of expression of GLUT12 was significantly higher in Alzheimer's disease compare to aged controls
      Title: Expression of the glucose transporter GLUT12 in Alzheimer's disease patients.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-glucose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in circulatory system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hexose transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 12
    Names
    GLUT-12
    glucose transporter type 12
    solute carrier family 2 (facilitated glucose transporter), member 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145176.3 → NP_660159.1  solute carrier family 2, facilitated glucose transporter member 12

      See identical proteins and their annotated locations for NP_660159.1

      Status: VALIDATED

      Source sequence(s)
      AL035699, AL833602, AY046419, DB253903
      Consensus CDS
      CCDS5169.1
      UniProtKB/Swiss-Prot
      B3KV17, Q7Z6U3, Q8TD20, Q96MR8
      Related
      ENSP00000275230.5, ENST00000275230.6
      Conserved Domains (1) summary
      pfam00083
      Location:44 → 561
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      133987581..134052624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010311.3 → XP_016865800.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X2

    2. XM_006715349.5 → XP_006715412.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X1

      Conserved Domains (2) summary
      cd06174
      Location:45 → 363
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG0477
      Location:43 → 371
      ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      135175590..135240550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354352.1 → XP_054210327.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X2

    2. XM_054354351.1 → XP_054210326.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TD20.1 GenPept UniProtKB/Swiss-Prot:Q8TD20

    Gene LinkOut

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