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    SPOP speckle type BTB/POZ protein [ Homo sapiens (human) ]

    Gene ID: 8405, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SPOPprovided by HGNC
    Official Full Name
    speckle type BTB/POZ proteinprovided by HGNC
    Primary source
    HGNC:HGNC:11254
    See related
    Ensembl:ENSG00000121067 MIM:602650; AllianceGenome:HGNC:11254
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TEF2; BTBD32; NSDVS1; NSDVS2; NEDMACE; NEDMIDF
    Summary
    This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 17.8), esophagus (RPKM 16.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SPOP in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (49598884..49678163, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (50462011..50541274, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47676246..47755525, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47587751-47588401 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:47588857-47589824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47590890-47591665 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47591666-47592440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47592441-47593216 Neighboring gene NGFR antisense RNA 1 Neighboring gene nerve growth factor receptor Neighboring gene microRNA 6165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47654119-47654649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47659009-47659562 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:47683760-47683957 Neighboring gene neurexophilin 3 Neighboring gene uncharacterized LOC107984999 Neighboring gene NANOG hESC enhancer GRCh37_chr17:47695165-47695679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47784629-47785262 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47785263-47785896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47796530-47797090 Neighboring gene solute carrier family 35 member B1 Neighboring gene family with sequence similarity 117 member A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8675 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47865191-47865964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12372 Neighboring gene lysine acetyltransferase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SPOP-mutant prostate cancer: Translating fundamental biology into patient care. Bernasocchi T, et al. Cancer Lett, 2022 Mar 31. PMID 34974131
    2. Deregulation of SPOP in Cancer. Zhang H, et al. Cancer Res, 2023 Feb 15. PMID 36512624
    3. Speckle-type POZ protein could play a potential inhibitory role in human renal cell carcinoma. Chen Z, et al. BMC Cancer, 2022 Dec 7. PMID 36474188, Free PMC Article
    4. SPOP in Cancer: Phenomena, Mechanisms and Its Role in Therapeutic Implications. Yang X, et al. Genes (Basel), 2022 Nov 7. PMID 36360288, Free PMC Article
    5. Relationship between SPOP mutation and breast cancer in Chinese population. Khan MA, et al. Genet Mol Res, 2015 Oct 16. PMID 26505385

    See all (213) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SPOP downregulation promotes bladder cancer progression based on cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis and is regulated by VEZF1.
      Title: SPOP downregulation promotes bladder cancer progression based on cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis and is regulated by VEZF1.
    2. ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance.
      Title: ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance.
    3. CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation.
      Title: CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation.
    4. Genetic Profiling of African American Patients With Prostatic Adenocarcinoma Metastatic to the Lymph Nodes: A Pilot Study.
      Title: Genetic Profiling of African American Patients With Prostatic Adenocarcinoma Metastatic to the Lymph Nodes: A Pilot Study.
    5. BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma.
      Title: BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma.
    6. Deficiency in SPOP-mediated ubiquitination and degradation of TIAM1 promotes gastric cancer progression.
      Title: Deficiency in SPOP-mediated ubiquitination and degradation of TIAM1 promotes gastric cancer progression.
    7. Ubiquitin E3 ligase SPOP is a host negative regulator of enterovirus 71-encoded 2A protease.
      Title: Ubiquitin E3 ligase SPOP is a host negative regulator of enterovirus 71-encoded 2A protease.
    8. SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer.
      Title: SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer.
    9. Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP.
      Title: Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP.
    10. SPOP inhibits HBV transcription and replication by ubiquitination and degradation of HNF1alpha.
      Title: SPOP inhibits HBV transcription and replication by ubiquitination and degradation of HNF1α.
    Submit: New GeneRIF Correction See all GeneRIFs (135)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Neurodevelopmental disorder with microcephaly and dysmorphic facies
    MedGen: C5394218 OMIM: 618828 GeneReviews: Not available
    		not available
    Neurodevelopmental disorder with relative macrocephaly and with or without cardiac or endocrine anomalies
    MedGen: C5394221 OMIM: 618829 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables molecular function inhibitor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    speckle-type POZ protein
    Names
    HIB homolog 1
    roadkill homolog 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_041815.1 RefSeqGene

      Range
      5067..84280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1412

    mRNA and Protein(s)

    1. NM_001007226.1 → NP_001007227.1  speckle-type POZ protein

      See identical proteins and their annotated locations for NP_001007227.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Transcript variants 1-6 encode the same protein.
      Source sequence(s)
      AK123385, AW449169, BC001269, BM693397, BQ226031, BX282325, W84567
      Consensus CDS
      CCDS11551.1
      UniProtKB/Swiss-Prot
      B2R6S3, D3DTW7, O43791, Q53HJ1
      UniProtKB/TrEMBL
      A8KAI0
      Related
      ENSP00000424119.2, ENST00000514121.6
      Conserved Domains (3) summary
      cd03774
      Location:28 → 166
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cd18279
      Location:182 → 301
      BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins
      cd18518
      Location:297 → 367
      BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)

    2. NM_001007227.1 → NP_001007228.1  speckle-type POZ protein

      See identical proteins and their annotated locations for NP_001007228.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Transcript variants 1-6 encode the same protein.
      Source sequence(s)
      AK123385, AW449169, BC001269, BM693397, BQ226031, BX282325, W84567
      Consensus CDS
      CCDS11551.1
      UniProtKB/Swiss-Prot
      B2R6S3, D3DTW7, O43791, Q53HJ1
      UniProtKB/TrEMBL
      A8KAI0
      Conserved Domains (3) summary
      cd03774
      Location:28 → 166
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cd18279
      Location:182 → 301
      BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins
      cd18518
      Location:297 → 367
      BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)

    3. NM_001007228.2 → NP_001007229.1  speckle-type POZ protein

      See identical proteins and their annotated locations for NP_001007229.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Transcript variants 1-6 encode the same protein.
      Source sequence(s)
      AK123385, AW449169, BC001269, BM693397, BQ226031, BX282325, W84567
      Consensus CDS
      CCDS11551.1
      UniProtKB/Swiss-Prot
      B2R6S3, D3DTW7, O43791, Q53HJ1
      UniProtKB/TrEMBL
      A8KAI0
      Related
      ENSP00000425905.1, ENST00000504102.6
      Conserved Domains (3) summary
      cd03774
      Location:28 → 166
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cd18279
      Location:182 → 301
      BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins
      cd18518
      Location:297 → 367
      BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)

    4. NM_001007229.1 → NP_001007230.1  speckle-type POZ protein

      See identical proteins and their annotated locations for NP_001007230.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Transcript variants 1-6 encode the same protein.
      Source sequence(s)
      AK123385, AW449169, BC001269, BM693397, BQ226031, BX282325, CB992730, W84567
      Consensus CDS
      CCDS11551.1
      UniProtKB/Swiss-Prot
      B2R6S3, D3DTW7, O43791, Q53HJ1
      UniProtKB/TrEMBL
      A8KAI0
      Related
      ENSP00000240327.2, ENST00000347630.6
      Conserved Domains (3) summary
      cd03774
      Location:28 → 166
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cd18279
      Location:182 → 301
      BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins
      cd18518
      Location:297 → 367
      BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)

    5. NM_001007230.1 → NP_001007231.1  speckle-type POZ protein

      See identical proteins and their annotated locations for NP_001007231.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Transcript variants 1-6 encode the same protein.
      Source sequence(s)
      AK123385, AW449169, BC001269, BM693397, BQ226031, BX282325, CB992730, W84567
      Consensus CDS
      CCDS11551.1
      UniProtKB/Swiss-Prot
      B2R6S3, D3DTW7, O43791, Q53HJ1
      UniProtKB/TrEMBL
      A8KAI0
      Related
      ENSP00000426986.2, ENST00000509079.6
      Conserved Domains (3) summary
      cd03774
      Location:28 → 166
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cd18279
      Location:182 → 301
      BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins
      cd18518
      Location:297 → 367
      BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)

    6. NM_001370730.1 → NP_001357659.1  speckle-type POZ protein

      Status: REVIEWED

      Source sequence(s)
      AC006487
      Consensus CDS
      CCDS11551.1
      UniProtKB/Swiss-Prot
      B2R6S3, D3DTW7, O43791, Q53HJ1
      UniProtKB/TrEMBL
      A8KAI0
      Related
      ENSP00000420908.1, ENST00000503676.5
      Conserved Domains (3) summary
      cd03774
      Location:28 → 166
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cd18279
      Location:182 → 301
      BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins
      cd18518
      Location:297 → 367
      BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)

    7. NM_001370731.1 → NP_001357660.1  speckle-type POZ protein

      Status: REVIEWED

      Source sequence(s)
      AC006487
      Consensus CDS
      CCDS11551.1
      UniProtKB/Swiss-Prot
      B2R6S3, D3DTW7, O43791, Q53HJ1
      UniProtKB/TrEMBL
      A8KAI0
      Conserved Domains (3) summary
      cd03774
      Location:28 → 166
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cd18279
      Location:182 → 301
      BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins
      cd18518
      Location:297 → 367
      BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)

    8. NM_001370732.1 → NP_001357661.1  speckle-type POZ protein

      Status: REVIEWED

      Source sequence(s)
      AC006487
      Consensus CDS
      CCDS11551.1
      UniProtKB/Swiss-Prot
      B2R6S3, D3DTW7, O43791, Q53HJ1
      UniProtKB/TrEMBL
      A8KAI0
      Conserved Domains (3) summary
      cd03774
      Location:28 → 166
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cd18279
      Location:182 → 301
      BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins
      cd18518
      Location:297 → 367
      BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)

    9. NM_003563.3 → NP_003554.1  speckle-type POZ protein

      See identical proteins and their annotated locations for NP_003554.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Transcript variants 1-6 encode the same protein.
      Source sequence(s)
      AK123385, AW449169, BC001269, BM693397, BQ226031, BX282325, W84567
      Consensus CDS
      CCDS11551.1
      UniProtKB/Swiss-Prot
      B2R6S3, D3DTW7, O43791, Q53HJ1
      UniProtKB/TrEMBL
      A8KAI0
      Related
      ENSP00000377001.2, ENST00000393328.6
      Conserved Domains (3) summary
      cd03774
      Location:28 → 166
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cd18279
      Location:182 → 301
      BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins
      cd18518
      Location:297 → 367
      BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      49598884..49678163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450995.2 → XP_024306763.1  speckle-type POZ protein isoform X1

      UniProtKB/Swiss-Prot
      B2R6S3, D3DTW7, O43791, Q53HJ1
      UniProtKB/TrEMBL
      A8KAI0
      Conserved Domains (3) summary
      cd03774
      Location:28 → 166
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cd18279
      Location:182 → 301
      BTB_POZ_SPOP-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins
      cd18518
      Location:297 → 367
      BACK_SPOP; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      50462011..50541274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317516.1 → XP_054173491.1  speckle-type POZ protein isoform X1

      UniProtKB/Swiss-Prot
      B2R6S3, D3DTW7, O43791, Q53HJ1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43791.1 GenPept UniProtKB/Swiss-Prot:O43791

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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    Tools
    Miscellaneous