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    Dcps decapping enzyme, scavenger [ Mus musculus (house mouse) ]

    Gene ID: 69305, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dcpsprovided by MGI
    Official Full Name
    decapping enzyme, scavengerprovided by MGI
    Primary source
    MGI:MGI:1916555
    See related
    Ensembl:ENSMUSG00000032040 AllianceGenome:MGI:1916555
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DCS-1; HINT-5; 1700001E16Rik
    Summary
    Predicted to enable 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity; RNA 7-methylguanosine cap binding activity; and identical protein binding activity. Predicted to be involved in deadenylation-dependent decapping of nuclear-transcribed mRNA and mRNA cis splicing, via spliceosome. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be active in P-body and nucleus. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human DCPS (decapping enzyme, scavenger). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 26.3), liver E14 (RPKM 24.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dcps in Genome Data Viewer
    Location:
    9 A4; 9 19.71 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35035710..35087283, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35124414..35175987, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Neighboring gene predicted gene, 51705 Neighboring gene STARR-seq mESC enhancer starr_23763 Neighboring gene RIKEN cDNA 4930581F22 gene Neighboring gene predicted gene, 57537 Neighboring gene predicted gene, 24262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:34983517-34983704 Neighboring gene STARR-positive B cell enhancer ABC_E6723 Neighboring gene toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Neighboring gene predicted gene, 39318 Neighboring gene STARR-positive B cell enhancer ABC_E5059 Neighboring gene FAD-dependent oxidoreductase domain containing 1 Neighboring gene signal recognition particle receptor alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution. Han GW, et al. Proteins, 2005 Sep 1. PMID 16001405
    2. The natural antisense transcript NATTD regulates the transcription of decapping scavenger (DcpS) enzyme. Mei ZZ, et al. Int J Biochem Cell Biol, 2019 May. PMID 30858142
    3. The DcpS inhibitor RG3039 improves motor function in SMA mice. Van Meerbeke JP, et al. Hum Mol Genet, 2013 Oct 15. PMID 23727836, Free PMC Article
    4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NATTD as a regulator of DcpS transcription through epigenetic mechanisms
      Title: The natural antisense transcript NATTD regulates the transcription of decapping scavenger (DcpS) enzyme.
    2. Amino acid sequence and xray crystallograpy structure given
      Title: Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA 7-methylguanosine cap binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA methylguanosine-cap decapping ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    m7GpppX diphosphatase
    Names
    decapping scavenger enzyme
    hint-related 7meGMP-directed hydrolase
    histidine triad nucleotide-binding protein 5
    histidine triad protein member 5
    mRNA decapping enzyme
    scavenger mRNA-decapping enzyme DcpS
    NP_081306.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027030.2 → NP_081306.1  m7GpppX diphosphatase

      See identical proteins and their annotated locations for NP_081306.1

      Status: PROVISIONAL

      Source sequence(s)
      AK005584
      Consensus CDS
      CCDS22957.1
      UniProtKB/Swiss-Prot
      Q8C5I7, Q9DAR7
      Related
      ENSMUSP00000034539.6, ENSMUST00000034539.12
      Conserved Domains (3) summary
      COG5075
      Location:46 → 320
      COG5075; Uncharacterized conserved protein [Function unknown]
      pfam05652
      Location:44 → 145
      DcpS; Scavenger mRNA decapping enzyme (DcpS) N-terminal
      pfam11969
      Location:174 → 281
      DcpS_C; Scavenger mRNA decapping enzyme C-term binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      35035710..35087283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAR7.1 GenPept UniProtKB/Swiss-Prot:Q9DAR7

    Gene LinkOut

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