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    ist-1 IRS-type PTB domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180978, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ist-1
    Official Full Name
    IRS-type PTB domain-containing protein
    Primary source
    WormBase:WBGene00002163
    Locus tag
    CELE_C54D1.3
    See related
    AllianceGenome:WB:WBGene00002163
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable insulin receptor binding activity; phosphatidylinositol 3-kinase binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in dauer larval development; insulin receptor signaling pathway; and short-term memory. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ist-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    19
    Sequence:
    Chromosome: X; NC_003284.9 (7126648..7139666)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene dual-specificity kinase Neighboring gene ncRNA Neighboring gene HEsitatioN behavior Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene Aldehyde dehydrogenase domain-containing protein Neighboring gene Laminin-like protein lam-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insulin/IGF signaling regulates presynaptic glutamate release in aversive olfactory learning. Cheng D, et al. Cell Rep, 2022 Nov 22. PMID 36417877
    2. Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. Wolkow CA, et al. J Biol Chem, 2002 Dec 20. PMID 12393910
    3. Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos. Frankel EB, et al. Nat Commun, 2017 Nov 13. PMID 29129923, Free PMC Article
    4. Ketone bodies mimic the life span extending properties of caloric restriction. Veech RL, et al. IUBMB Life, 2017 May. PMID 28371201
    5. Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Martins R, et al. Aging Cell, 2016 Apr. PMID 26643314, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors show that membrane bending and intralumenal vesicle formation are directed specifically by the ESCRT-III complex in vivo in a manner regulated by Ist1, which promotes ESCRT-III assembly and inhibits the incorporation of upstream ESCRT components into intralumenal vesicles.
      Title: Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos.
    2. IST-1 appears to be required for signaling through a pathway that may act in parallel to AGE-1/PI3K
      Title: Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables insulin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphatidylinositol 3-kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in short-term memory IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    IRS-type PTB domain-containing protein
    NP_001317892.1
    • Confirmed by transcript evidence
    NP_001360631.1
    • Confirmed by transcript evidence
    NP_001360716.1
    • Confirmed by transcript evidence
    NP_509201.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7126648..7139666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330903.3 → NP_001317892.1  IRS-type PTB domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1C3NSK8, Q8WQL8

    2. NM_001373345.2 → NP_001360631.1  IRS-type PTB domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IIP8, Q8WQL8
      Conserved Domains (1) summary
      cl17171
      Location:213 → 301
      PH-like; Pleckstrin homology-like domain

    3. NM_076800.7 → NP_509201.3  IRS-type PTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509201.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18820, Q8WQL8
      Conserved Domains (1) summary
      cl17171
      Location:123 → 211
      PH-like; Pleckstrin homology-like domain

    4. NM_001373346.3 → NP_001360716.1  IRS-type PTB domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0INB3, Q8WQL8
      Conserved Domains (1) summary
      cl17171
      Location:123 → 211
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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