Arhgap17 Rho GTPase activating protein 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap17provided by MGI
Official Full Name: Rho GTPase activating protein 17provided by MGI
Primary source: MGI:MGI:1917747
See related: Ensembl:ENSMUSG00000030766 AllianceGenome:MGI:1917747
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rich1; Wbp15; Nadrin; Nadrin2; 5730403H17Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction; regulation of Rac protein signal transduction; and regulation of actin cytoskeleton organization. Predicted to act upstream of or within actin filament organization and calcium-ion regulated exocytosis. Located in plasma membrane. Is expressed in facial prominence ectoderm; limb; and limb mesenchyme. Orthologous to human ARHGAP17 (Rho GTPase activating protein 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 26.2), adrenal adult (RPKM 21.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 67.42 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (122878372..122969171, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (123279149..123369948, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arhgap17 regulates mucosal and epithelial barrier function in the mouse colon.
Title: Arhgap17, a RhoGTPase activating protein, regulates mucosal and epithelial barrier function in the mouse colon.
The phosphorylation of Nadrin leads to tightly regulated Rho activation that was found to be Nadrin isoform- and (Rho) target-specific.
Title: Nadrin GAP activity is isoform- and target-specific regulated by tyrosine phosphorylation.
NADRIN is associated with the ERM protein complex, where it inactivates RhoA and leads to the morphological differentiation of astrocytes.
Title: The role of NADRIN, a Rho GTPase-activating protein, in the morphological differentiation of astrocytes.
A critical role for Nadrin in the regulation of RhoA, Cdc42 and Rac1 in platelets and thus for platelet adhesion and aggregation.
Title: Isoform-specific roles of the GTPase activating protein Nadrin in cytoskeletal reorganization of platelets.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127120 (e-PCR)
- UniSTS:167515

Arhgap17 (e-PCR), detects polymorphism
- UniSTS:527253

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium-ion regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of small GTPase mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 17

Names: WW domain-binding protein 15; neuron-associated developmentally regulated protein; rho-type GTPase-activating protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122640.1 → NP_001116112.1 rho GTPase-activating protein 17 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region compared to variant 1 that results in a frameshift. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AI842721, AK147010, AK152266, AK161636, AV321044

Consensus CDS

CCDS52390.1

UniProtKB/TrEMBL

E9QAJ9

Related

ENSMUSP00000128447.2, ENSMUST00000167309.8

Conserved Domains (2) summary

cd07618
Location:13 → 257

BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1

cd04386
Location:246 → 446

RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
NM_001122641.1 → NP_001116113.1 rho GTPase-activating protein 17 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an exon in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter but has the same N- and C-termini compared to isoform a.

Source sequence(s)

AI842721, AK147010, AK152266, AK161636, AV321044

Consensus CDS

CCDS85404.1

UniProtKB/Swiss-Prot

Q3UIA2

Related

ENSMUSP00000095668.5, ENSMUST00000098060.5

Conserved Domains (2) summary

cd07618
Location:13 → 257

BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1

cd04386
Location:246 → 446

RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
NM_001122642.1 → NP_001116114.1 rho GTPase-activating protein 17 isoform d

See identical proteins and their annotated locations for NP_001116114.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences in the coding region compared to variant 1, one of which results in a frameshift. The resulting protein (isoform d) is shorter and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AI842721, AK147010, AK152266, AK161636, AV321044

Consensus CDS

CCDS85405.1

UniProtKB/Swiss-Prot

Q3UIA2

Related

ENSMUSP00000145628.2, ENSMUST00000207010.2

Conserved Domains (2) summary

cd07618
Location:13 → 257

BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1

cd04386
Location:246 → 446

RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
NM_001122643.1 → NP_001116115.1 rho GTPase-activating protein 17 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (5) has multiple differences in the coding region compared to variant 1, one of which results in a frameshift. The resulting protein (isoform e) is shorter and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AI842721, AK046411, AK147010, AK152266, AK161636, AV321044

Consensus CDS

CCDS52388.1

UniProtKB/Swiss-Prot

Q3UIA2

Related

ENSMUSP00000146035.2, ENSMUST00000205262.2

Conserved Domains (2) summary

cd07618
Location:13 → 257

BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1

cd04386
Location:246 → 446

RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
NM_001316713.1 → NP_001303642.1 rho GTPase-activating protein 17 isoform f

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks an alternate exon in the middle of the transcript and contains an alternate exon in the 3' end compared to variant 1. The resulting isoform (f) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC138364, AI842721, AK046411, AK149986, AK161636

UniProtKB/Swiss-Prot

Q3UIA2

Conserved Domains (1) summary

cd04386
Location:1 → 173

RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...
NM_144529.2 → NP_653112.2 rho GTPase-activating protein 17 isoform a

See identical proteins and their annotated locations for NP_653112.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest protein (isoform a).

Source sequence(s)

AI842721, AK147010, AK152266, AK161636, AV321044

Consensus CDS

CCDS52389.1

UniProtKB/Swiss-Prot

Q3UDP7, Q3UIA2, Q8BGD1, Q99LH3, Q99N39, Q99N40

Related

ENSMUSP00000102050.3, ENSMUST00000106442.9

Conserved Domains (2) summary

cd07618
Location:13 → 257

BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1

cd04386
Location:246 → 446

RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

122878372..122969171 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508201.4 → XP_006508264.1 rho GTPase-activating protein 17 isoform X1

Conserved Domains (2) summary

cd07618
Location:13 → 257

BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1

cd04386
Location:246 → 446

RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
XM_030242982.1 → XP_030098842.1 rho GTPase-activating protein 17 isoform X2

Conserved Domains (1) summary

cd04386
Location:1 → 173

RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...