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    Rab24 RAB24, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19336, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rab24provided by MGI
    Official Full Name
    RAB24, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:105065
    See related
    Ensembl:ENSMUSG00000034789 AllianceGenome:MGI:105065
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6530406O07Rik
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Located in autophagosome. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human RAB24 (RAB24, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 32.6), CNS E11.5 (RPKM 31.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rab24 in Genome Data Viewer
    Location:
    13 B1; 13 29.8 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55467036..55469807, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55319223..55321980, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor 4 Neighboring gene STARR-positive B cell enhancer ABC_E5399 Neighboring gene STARR-seq mESC enhancer starr_34607 Neighboring gene nuclear receptor-binding SET-domain protein 1 Neighboring gene STARR-seq mESC enhancer starr_34609 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:55429152-55429261 Neighboring gene PRELI domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_34614 Neighboring gene Max dimerization protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E7242 Neighboring gene lectin, mannose-binding 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tyrosine phosphorylation of the Rab24 GTPase in cultured mammalian cells. Ding J, et al. Biochem Biophys Res Commun, 2003 Dec 19. PMID 14680817
    2. Rab24 functions in meiotic apparatus assembly and maturational progression in mouse oocyte. Qiu D, et al. Cell Cycle, 2019 Nov. PMID 31496367, Free PMC Article
    3. RAB24 facilitates clearance of autophagic compartments during basal conditions. Ylä-Anttila P, et al. Autophagy, 2015. PMID 26325487, Free PMC Article
    4. Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily. Olkkonen VM, et al. J Cell Sci, 1993 Dec. PMID 8126105
    5. The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum. Tambe Y, et al. Cancer Lett, 2009 Sep 28. PMID 19368996

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    ras-related protein Rab-24
    Names
    rab-16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429097.1 → NP_001416026.1  ras-related protein Rab-24 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC160958

    2. NM_001429098.1 → NP_001416027.1  ras-related protein Rab-24 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC160958

    3. NM_001429099.1 → NP_001416028.1  ras-related protein Rab-24 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC160958

    4. NM_001429100.1 → NP_001416029.1  ras-related protein Rab-24 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC160958

    5. NM_001429101.1 → NP_001416030.1  ras-related protein Rab-24 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC160958

    6. NM_001429102.1 → NP_001416031.1  ras-related protein Rab-24 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC160958

    7. NM_001429103.1 → NP_001416032.1  ras-related protein Rab-24 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC160958

    8. NM_001429104.1 → NP_001416033.1  ras-related protein Rab-24 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC160958

    9. NM_001429105.1 → NP_001416034.1  ras-related protein Rab-24 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC160958

    10. NM_001429106.1 → NP_001416035.1  ras-related protein Rab-24 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC160958

    11. NM_001429107.1 → NP_001416036.1  ras-related protein Rab-24 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC160958

    12. NM_009000.4 → NP_033026.1  ras-related protein Rab-24 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC160958
      Consensus CDS
      CCDS26541.1
      UniProtKB/Swiss-Prot
      P35290
      UniProtKB/TrEMBL
      Q0PD31, Q8K133
      Related
      ENSMUSP00000046188.8, ENSMUST00000035242.9
      Conserved Domains (1) summary
      cd04118
      Location:8 → 201
      Rab24; Rab GTPase family 24 (Rab24)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      55467036..55469807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517165.5 → XP_006517228.1  ras-related protein Rab-24 isoform X1

      Conserved Domains (1) summary
      cd04118
      Location:8 → 183
      Rab24; Rab GTPase family 24 (Rab24)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35290.2 GenPept UniProtKB/Swiss-Prot:P35290

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