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    tos tosca [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35119, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tosprovided by FlyBase
    Official Full Name
    toscaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015553
    Locus tag
    Dmel_CG10387
    See related
    AllianceGenome:FB:FBgn0015553
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10387; Dmel\CG10387; DmTosca; Tosca
    Summary
    Predicted to enable 5'-flap endonuclease activity; double-stranded DNA 5'-3' DNA exonuclease activity; and single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in DNA recombination and mismatch repair. Predicted to be active in nucleus. Is expressed in border follicle cell; germarium region 2a; germarium region 2b; germarium region 3; and oocyte. Orthologous to human EXO1 (exonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tos in Genome Data Viewer
    Location:
    36F11-36F11; 2-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18679631..18682075, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18679631..18682075, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Male-specific transcript 36Fb Neighboring gene Male-specific transcript 36Fa Neighboring gene uncharacterized protein Neighboring gene male-specific lethal 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DmGEN, a novel RAD2 family endo-exonuclease from Drosophila melanogaster. Ishikawa G, et al. Nucleic Acids Res, 2004. PMID 15576351, Free PMC Article
    2. Identification of in vivo DNA targets of chromatin proteins using tethered dam methyltransferase. van Steensel B, et al. Nat Biotechnol, 2000 Apr. PMID 10748524
    3. Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A. Janssen A, et al. Genes Dev, 2019 Jan 1. PMID 30578303, Free PMC Article
    4. Tosca: a Drosophila gene encoding a nuclease specifically expressed in the female germline. Digilio FA, et al. Dev Biol, 1996 Aug 25. PMID 8812111
    5. Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Chiolo I, et al. Cell, 2011 Mar 4. PMID 21353298, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-3' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' DNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-3' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA 5'-3' DNA exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables flap endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA 5'-3' DNA exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tosca
    Names
    CG10387-PA
    tos-PA
    NP_477145.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18679631..18682075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057797.4 → NP_477145.1  tosca [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477145.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9EQW7, Q24557, Q24558, Q960X5
      Related
      FBpp0080675
      Conserved Domains (2) summary
      cd09908
      Location:214 → 291
      H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09857
      Location:1 → 204
      PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24558.1 Q24558

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