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    Nmd3 Nonsense-mediated mRNA 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nmd3provided by FlyBase
    Official Full Name
    Nonsense-mediated mRNA 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0023542
    Locus tag
    Dmel_CG3460
    See related
    AllianceGenome:FB:FBgn0023542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-2Eb; CG3460; Dmel\CG3460; dNmd3; EG:152A3.1; II; TcD12; TcD13
    Summary
    Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in ribosomal large subunit export from nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; gut section; and larval somatic muscle cell. Orthologous to human NMD3 (NMD3 ribosome export adaptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nmd3 in Genome Data Viewer
    Location:
    2E1-2E1; 1-0.8 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2182818..2184668, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2076851..2078701, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44690 Neighboring gene Cytochrome P450 4d2 Neighboring gene Cytochrome P450 4ae1 Neighboring gene prune Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the prune locus of Drosophila melanogaster. Teng DH, et al. Genetics, 1991 Jun. PMID 1649071, Free PMC Article
    2. A product of the prune locus of Drosophila is similar to mammalian GTPase-activating protein. Teng DH, et al. Nature, 1991 Oct 3. PMID 1654526
    3. Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis. Pulianmackal AJ, et al. Dis Model Mech, 2022 Mar 1. PMID 35107131, Free PMC Article
    4. Molecular analysis of a cytochrome P450 gene of family 4 on the Drosophila X chromosome. Gandhi R, et al. DNA Cell Biol, 1992 Jun. PMID 1605861
    5. Evidence for a selective sweep in the wapl region of Drosophila melanogaster. Beisswanger S, et al. Genetics, 2006 Jan. PMID 16204208, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal large subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosomal large subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Nonsense-mediated mRNA 3
    Names
    CG3460-PA
    Nmd3-PA
    transcription unit III

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2182818..2184668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057984.5 → NP_477332.1  Nonsense-mediated mRNA 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477332.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46050, Q9UB80
      Related
      FBpp0070409
      Conserved Domains (2) summary
      COG1499
      Location:21 → 390
      NMD3; NMD protein affecting ribosome stability and mRNA decay [Translation, ribosomal structure and biogenesis]
      pfam04981
      Location:27 → 255
      NMD3; NMD3 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46050 O46050
    Q9UB80 Q9UB80

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