Septin4 septin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Septin4provided by MGI
Official Full Name: septin 4provided by MGI
Primary source: MGI:MGI:1270156
See related: Ensembl:ENSMUSG00000020486 AllianceGenome:MGI:1270156
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bh5; ARTS; Sept4; Pnutl2; Gm11492; hCDCREL-2
Summary: Predicted to enable several functions, including GTP binding activity; GTPase activity; and magnesium ion binding activity. Involved in several processes, including flagellated sperm motility; hematopoietic stem cell homeostasis; and negative regulation of stem cell proliferation. Acts upstream of or within brain development; sperm capacitation; and sperm mitochondrion organization. Located in several cellular components, including axon terminus; perikaryon; and sperm annulus. Part of septin complex. Is expressed in several structures, including central nervous system; sensory organ; and testis. Orthologous to human SEPTIN4 (septin 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 67.1), testis adult (RPKM 31.3) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 52.14 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (87457515..87481365)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (87566689..87590543)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARTS is essential for di-2-ethylhexyl phthalate (DEHP)-induced apoptosis of mouse Leydig cells.
Title: ARTS is essential for di-2-ethylhexyl phthalate (DEHP)-induced apoptosis of mouse Leydig cells.
Proper phosphorylation of septin 12 regulates septin 4 and soluble adenylyl cyclase expression to induce sperm capacitation.
Title: Proper phosphorylation of septin 12 regulates septin 4 and soluble adenylyl cyclase expression to induce sperm capacitation.
Deacetylation of Septin4 by SIRT2 (Silent Mating Type Information Regulation 2 Homolog-2) Mitigates Damaging of Hypertensive Nephropathy.
Title: Deacetylation of Septin4 by SIRT2 (Silent Mating Type Information Regulation 2 Homolog-2) Mitigates Damaging of Hypertensive Nephropathy.
Septin 4 controls CCNB1 stabilization via APC/C(CDC20) during meiotic G2/M transition in mouse oocytes.
Title: Septin 4 controls CCNB1 stabilization via APC/C(CDC20) during meiotic G2/M transition in mouse oocytes.
The pro-apoptotic ARTS protein induces neutrophil apoptosis, efferocytosis, and macrophage reprogramming to promote resolution of inflammation.
Title: The pro-apoptotic ARTS protein induces neutrophil apoptosis, efferocytosis, and macrophage reprogramming to promote resolution of inflammation.
Septin4 as an autophagy modulator regulates Angiotensin-II mediated VSMCs proliferation and migration.
Title: Septin4 as an autophagy modulator regulates Angiotensin-II mediated VSMCs proliferation and migration.
the pro-apoptotic protein ARTS (a Septin4 isoform) is highly expressed in cells comprising the intestinal stem cell niche and that its deletion protects Lgr5(+) and Paneth cells from undergoing apoptotic cell death.
Title: ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.
Adenovirus-Sept4 can attenuate the development of liver fibrosis induced by S. japonicum through apoptosis.
Title: Adenovirus-mediated over-expression of Septin4 ameliorates hepatic fibrosis in mouse livers infected with Schistosoma japonicum.
The inhibition of the expression of the SEPT4 by praziquantel might be due to alleviation of the inflammatory response at the chronic and advanced stage of S. japonicum infection.
Title: Expression of Septin4 in Schistosoma japonicum-infected mouse livers after praziquantel treatment.
The hypothetical pathogenicity by the chronic overload of SEPT4 alone, if any, is insufficient to trigger neurodegenerative process in the mouse brain.
Title: Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

X61452 (e-PCR)
- UniSTS:125828

RH129619 (e-PCR)
- UniSTS:212916

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sperm capacitation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sperm mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dopaminergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in motile cilium	IMP Inferred from Mutant Phenotype more info	PubMed
located_in myelin sheath	HDA more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	IDA Inferred from Direct Assay more info	PubMed
part_of septin complex	ISO Inferred from Sequence Orthology more info
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm annulus	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm annulus	IDA Inferred from Direct Assay more info	PubMed
located_in sperm annulus	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: septin-4

Names: CE5B3 beta; M-Septin; bradeion beta; brain protein H5; cell division control-related protein 2; cell division control-related protein 2b; peanut-like 2 homolog; peanut-like protein 2; septin H5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001284392.2 → NP_001271321.1 septin-4 isoform 2

See identical proteins and their annotated locations for NP_001271321.1

Status: VALIDATED

Source sequence(s)

AL596086

Consensus CDS

CCDS70277.1

UniProtKB/Swiss-Prot

P28661

Related

ENSMUSP00000060127.5, ENSMUST00000063156.11

Conserved Domains (2) summary

COG5019
Location:25 → 377

CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

pfam00735
Location:42 → 315

Septin; Septin
NM_001284394.2 → NP_001271323.1 septin-4 isoform 3

See identical proteins and their annotated locations for NP_001271323.1

Status: VALIDATED

Source sequence(s)

AL596086

Consensus CDS

CCDS70276.1

UniProtKB/Swiss-Prot

P28661

Related

ENSMUSP00000103594.2, ENSMUST00000107960.8

Conserved Domains (1) summary

pfam00735
Location:141 → 421

Septin
NM_001284398.2 → NP_001271327.1 septin-4 isoform 4

See identical proteins and their annotated locations for NP_001271327.1

Status: VALIDATED

Source sequence(s)

AL596086

Consensus CDS

CCDS70275.1

UniProtKB/Swiss-Prot

P28661

Related

ENSMUSP00000112960.2, ENSMUST00000122067.8

Conserved Domains (1) summary

pfam00735
Location:24 → 296

Septin
NM_001361936.2 → NP_001348865.1 septin-4 isoform 5

Status: VALIDATED

Source sequence(s)

AL596086

Consensus CDS

CCDS88214.1

Related

ENSMUSP00000103596.2, ENSMUST00000107962.8

Conserved Domains (1) summary

pfam00735
Location:122 → 402

Septin
NM_001368775.2 → NP_001355704.1 septin-4 isoform 6

Status: VALIDATED

Source sequence(s)

AL596086

Conserved Domains (2) summary

pfam00735
Location:635 → 907

Septin

pfam15548
Location:14 → 509

DUF4655; Domain of unknown function (DUF4655)
NM_001368776.2 → NP_001355705.1 septin-4 isoform 7

Status: VALIDATED

Source sequence(s)

AL596086

Conserved Domains (1) summary

pfam00735
Location:135 → 407

Septin
NM_001368777.2 → NP_001355706.1 septin-4 isoform 8

Status: VALIDATED

Source sequence(s)

AL596086

Related

ENSMUST00000133638.8

Conserved Domains (1) summary

pfam00735
Location:24 → 296

Septin
NM_001368778.2 → NP_001355707.1 septin-4 isoform 9

Status: VALIDATED

Source sequence(s)

AL596086

Conserved Domains (1) summary

pfam00735
Location:122 → 402

Septin
NM_001368779.2 → NP_001355708.1 septin-4 isoform 10

Status: VALIDATED

Source sequence(s)

AL596086

Conserved Domains (1) summary

pfam00735
Location:135 → 407

Septin
NM_001424196.1 → NP_001411125.1 septin-4 isoform 11

Status: VALIDATED

Source sequence(s)

AL596086

UniProtKB/TrEMBL

A0A5F8MP96

Related

ENSMUSP00000158869.2, ENSMUST00000239011.2
NM_011129.3 → NP_035259.1 septin-4 isoform 1

See identical proteins and their annotated locations for NP_035259.1

Status: VALIDATED

Source sequence(s)

AL596086

Consensus CDS

CCDS25213.1

UniProtKB/Swiss-Prot

B2KGM3, B2KGM6, P28661, Q3UVH1, Q3UZC3, Q5ND10, Q5ND15, Q5ND16, Q5ND19, Q7TPM7, Q80VX1

Related

ENSMUSP00000018544.6, ENSMUST00000018544.12

Conserved Domains (1) summary

pfam00735
Location:141 → 421

Septin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

87457515..87481365

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245663.2 → XP_030101523.1 septin-4 isoform X2

Conserved Domains (2) summary

pfam15548
Location:14 → 509

DUF4655; Domain of unknown function (DUF4655)

cl38985
Location:634 → 759

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_030245665.2 → XP_030101525.1 septin-4 isoform X6

Conserved Domains (1) summary

pfam00735
Location:35 → 315

Septin
XM_036156427.1 → XP_036012320.1 septin-4 isoform X10

Conserved Domains (1) summary

pfam00735
Location:1 → 232

Septin
XM_036156428.1 → XP_036012321.1 septin-4 isoform X10

Conserved Domains (1) summary

pfam00735
Location:1 → 232

Septin
XM_036156425.1 → XP_036012318.1 septin-4 isoform X3

Conserved Domains (1) summary

pfam00735
Location:134 → 406

Septin
XM_036156426.1 → XP_036012319.1 septin-4 isoform X7

Conserved Domains (1) summary

pfam00735
Location:35 → 307

Septin
XM_030245666.2 → XP_030101526.1 septin-4 isoform X8

Conserved Domains (1) summary

pfam00735
Location:43 → 315

Septin
XM_030245664.2 → XP_030101524.1 septin-4 isoform X5

Conserved Domains (1) summary

pfam00735
Location:131 → 411

Septin
XM_006532497.4 → XP_006532560.1 septin-4 isoform X4

See identical proteins and their annotated locations for XP_006532560.1

Conserved Domains (1) summary

pfam00735
Location:131 → 411

Septin
XM_030245667.1 → XP_030101527.1 septin-4 isoform X9

Conserved Domains (1) summary

pfam00735
Location:1 → 267

Septin