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    Zfp454 zinc finger protein 454 [ Mus musculus (house mouse) ]

    Gene ID: 237758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp454provided by MGI
    Official Full Name
    zinc finger protein 454provided by MGI
    Primary source
    MGI:MGI:2679253
    See related
    Ensembl:ENSMUSG00000048728 AllianceGenome:MGI:2679253
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230342N19
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human ZNF454 (zinc finger protein 454). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 2.3), CNS E14 (RPKM 2.1) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp454 in Genome Data Viewer
    Location:
    11 B1.3; 11 30.94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50763545..50778463, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50872718..50887634, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 879 Neighboring gene STARR-positive B cell enhancer ABC_E6979 Neighboring gene glutamate receptor, metabotropic 6 Neighboring gene STARR-seq mESC enhancer starr_29409 Neighboring gene zinc finger protein 2 Neighboring gene zinc finger protein 354B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC57560

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 454

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359531.1 → NP_001346460.1  zinc finger protein 454 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate start codon and lacks three coding exons, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK046117, BC049793
      UniProtKB/TrEMBL
      Q8BIK0
      Conserved Domains (2) summary
      COG5048
      Location:135 → 447
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001382449.1 → NP_001369378.1  zinc finger protein 454 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL627215
      Conserved Domains (3) summary
      smart00349
      Location:14 → 66
      KRAB; krueppel associated box
      COG5048
      Location:196 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:343 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001382450.1 → NP_001369379.1  zinc finger protein 454 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL627215
      Conserved Domains (3) summary
      smart00349
      Location:14 → 66
      KRAB; krueppel associated box
      COG5048
      Location:196 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:343 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001382451.1 → NP_001369380.1  zinc finger protein 454 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL627215
      UniProtKB/TrEMBL
      Q80Y34
      Related
      ENSMUSP00000129125.2, ENSMUST00000163301.8
      Conserved Domains (3) summary
      smart00349
      Location:14 → 67
      KRAB; krueppel associated box
      COG5048
      Location:197 → 532
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:344 → 364
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001382452.1 → NP_001369381.1  zinc finger protein 454 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627215
      Conserved Domains (2) summary
      COG5048
      Location:163 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001382453.1 → NP_001369382.1  zinc finger protein 454 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627215
      Conserved Domains (2) summary
      COG5048
      Location:163 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001382454.1 → NP_001369383.1  zinc finger protein 454 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL627215
      Conserved Domains (2) summary
      COG5048
      Location:133 → 468
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:280 → 300
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001382455.1 → NP_001369384.1  zinc finger protein 454 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL627215
      Conserved Domains (2) summary
      COG5048
      Location:133 → 468
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:280 → 300
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_001382456.1 → NP_001369385.1  zinc finger protein 454 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL627215
      Conserved Domains (2) summary
      COG5048
      Location:142 → 477
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:289 → 309
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. NM_001382457.1 → NP_001369386.1  zinc finger protein 454 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL627215
      Conserved Domains (2) summary
      COG5048
      Location:164 → 499
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311 → 331
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. NM_172794.3 → NP_766382.2  zinc finger protein 454 isoform 1

      See identical proteins and their annotated locations for NP_766382.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK046117, BC049793
      Consensus CDS
      CCDS24639.1
      UniProtKB/TrEMBL
      Q80Y34
      Related
      ENSMUSP00000061824.7, ENSMUST00000050595.13
      Conserved Domains (3) summary
      smart00349
      Location:14 → 67
      KRAB; krueppel associated box
      COG5048
      Location:197 → 532
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:344 → 364
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      50763545..50778463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245962.2 → XP_030101822.1  zinc finger protein 454 isoform X1

      UniProtKB/TrEMBL
      Q8BIK0
      Conserved Domains (2) summary
      COG5048
      Location:135 → 447
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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