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    Zmiz2 zinc finger, MIZ-type containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 52915, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zmiz2provided by MGI
    Official Full Name
    zinc finger, MIZ-type containing 2provided by MGI
    Primary source
    MGI:MGI:106374
    See related
    Ensembl:ENSMUSG00000041164 AllianceGenome:MGI:106374
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zimp7
    Summary
    Predicted to enable SUMO ligase activity and nuclear receptor coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and protein sumoylation. Predicted to be located in chromatin; mitochondrion; and nuclear lumen. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ZMIZ2 (zinc finger MIZ-type containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 50.9), spleen adult (RPKM 44.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zmiz2 in Genome Data Viewer
    Location:
    11 A1; 11 3.95 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6339063..6356158)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6388799..6406162)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6948 Neighboring gene STARR-positive B cell enhancer ABC_E2347 Neighboring gene predicted gene, 46270 Neighboring gene oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28459 Neighboring gene STARR-seq mESC enhancer starr_28461 Neighboring gene STARR-seq mESC enhancer starr_28463 Neighboring gene microRNA 7651 Neighboring gene STARR-positive B cell enhancer ABC_E5206 Neighboring gene peptidylprolyl isomerase A Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:6344510-6344697 Neighboring gene H2A.Z histone variant 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spatial and temporal expression of Zimp7 and Zimp10 PIAS-like proteins in the developing mouse embryo. Rodriguez-Magadán H, et al. Gene Expr Patterns, 2008 Feb. PMID 18053775
    2. Identification of a novel role of ZMIZ2 protein in regulating the activity of the Wnt/β-catenin signaling pathway. Lee SH, et al. J Biol Chem, 2013 Dec 13. PMID 24174533, Free PMC Article
    3. Sexually dimorphic gene expression of the Zimp7 and Zimp10 genes in embryonic gonads. Rodríguez-Magadán H, et al. Gene Expr Patterns, 2010 Jan. PMID 19931425
    4. A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription. Peng Y, et al. J Biol Chem, 2010 Apr 9. PMID 20159969, Free PMC Article
    5. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a novel interaction between ZMIZ2 and beta-caten
      Title: Identification of a novel role of ZMIZ2 protein in regulating the activity of the Wnt/β-catenin signaling pathway.
    2. Zimp7 is expressed in germ cells of the embryonic gonad and the adult testis.
      Title: Sexually dimorphic gene expression of the Zimp7 and Zimp10 genes in embryonic gonads.
    3. there is an interaction between Zimp7 and PIAS proteins with higher preference for PIAS3, in androgen receptor-mediated transcription
      Title: A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • 2410117E06Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear replication fork ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger MIZ domain-containing protein 2
    Names
    PIAS-like protein Zimp7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005867.2 → NP_001005867.1  zinc finger MIZ domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001005867.1

      Status: VALIDATED

      Source sequence(s)
      AL607152
      Consensus CDS
      CCDS24417.1
      UniProtKB/Swiss-Prot
      Q8CIE2
      Conserved Domains (2) summary
      PHA03307
      Location:682 → 855
      PHA03307; transcriptional regulator ICP4; Provisional
      cd16791
      Location:565 → 612
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    2. NM_001425569.1 → NP_001412498.1  zinc finger MIZ domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL607152
      UniProtKB/Swiss-Prot
      Q5SVX4, Q5SVX5, Q5SVX6, Q6P558, Q6P9Q5, Q8BJ00, Q8CIE2
      Related
      ENSMUSP00000012612.5, ENSMUST00000012612.11

    3. NM_001425570.1 → NP_001412499.1  zinc finger MIZ domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL607152

    4. NM_001425571.1 → NP_001412500.1  zinc finger MIZ domain-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL607152

    5. NM_001425572.1 → NP_001412501.1  zinc finger MIZ domain-containing protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL607152

    6. NM_028601.4 → NP_082877.2  zinc finger MIZ domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_082877.2

      Status: VALIDATED

      Source sequence(s)
      AL607152
      Consensus CDS
      CCDS24418.1
      UniProtKB/Swiss-Prot
      Q5SVX4, Q5SVX5, Q5SVX6, Q6P558, Q6P9Q5, Q8BJ00, Q8CIE2
      Related
      ENSMUSP00000105410.2, ENSMUST00000109787.8
      Conserved Domains (2) summary
      PHA03307
      Location:714 → 887
      PHA03307; transcriptional regulator ICP4; Provisional
      cd16791
      Location:597 → 644
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    RNA

    1. NR_189321.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL607152

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      6339063..6356158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246147.2 → XP_030102007.1  zinc finger MIZ domain-containing protein 2 isoform X4

      Conserved Domains (2) summary
      PHA03307
      Location:680 → 853
      PHA03307; transcriptional regulator ICP4; Provisional
      cd16791
      Location:563 → 610
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    2. XM_030246142.2 → XP_030102002.1  zinc finger MIZ domain-containing protein 2 isoform X2

      Related
      ENSMUSP00000105408.2, ENSMUST00000109785.2
      Conserved Domains (2) summary
      PHA03307
      Location:688 → 861
      PHA03307; transcriptional regulator ICP4; Provisional
      cd16791
      Location:571 → 618
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    3. XM_030246144.2 → XP_030102004.1  zinc finger MIZ domain-containing protein 2 isoform X3

      Related
      ENSMUSP00000099978.4, ENSMUST00000102914.10
      Conserved Domains (2) summary
      PHA03307
      Location:682 → 855
      PHA03307; transcriptional regulator ICP4; Provisional
      cd16791
      Location:565 → 612
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    4. XM_030246149.2 → XP_030102009.1  zinc finger MIZ domain-containing protein 2 isoform X6

      Conserved Domains (2) summary
      PHA03307
      Location:648 → 821
      PHA03307; transcriptional regulator ICP4; Provisional
      cd16791
      Location:531 → 578
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    5. XM_006514748.4 → XP_006514811.1  zinc finger MIZ domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006514811.1

      UniProtKB/Swiss-Prot
      Q5SVX4, Q5SVX5, Q5SVX6, Q6P558, Q6P9Q5, Q8BJ00, Q8CIE2
      Conserved Domains (2) summary
      PHA03307
      Location:714 → 887
      PHA03307; transcriptional regulator ICP4; Provisional
      cd16791
      Location:597 → 644
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    6. XM_011243734.4 → XP_011242036.1  zinc finger MIZ domain-containing protein 2 isoform X4

      Conserved Domains (2) summary
      PHA03307
      Location:680 → 853
      PHA03307; transcriptional regulator ICP4; Provisional
      cd16791
      Location:563 → 610
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    7. XM_011243733.4 → XP_011242035.1  zinc finger MIZ domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8CIE2
      Conserved Domains (2) summary
      PHA03307
      Location:688 → 861
      PHA03307; transcriptional regulator ICP4; Provisional
      cd16791
      Location:571 → 618
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    8. XM_017314664.3 → XP_017170153.1  zinc finger MIZ domain-containing protein 2 isoform X6

      Conserved Domains (2) summary
      PHA03307
      Location:648 → 821
      PHA03307; transcriptional regulator ICP4; Provisional
      cd16791
      Location:531 → 578
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    9. XM_011243735.4 → XP_011242037.1  zinc finger MIZ domain-containing protein 2 isoform X5

      Conserved Domains (2) summary
      PHA03307
      Location:656 → 829
      PHA03307; transcriptional regulator ICP4; Provisional
      cd16791
      Location:539 → 586
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CIE2.2 GenPept UniProtKB/Swiss-Prot:Q8CIE2

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