Apol9b apolipoprotein L 9b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apol9bprovided by MGI
Official Full Name: apolipoprotein L 9bprovided by MGI
Primary source: MGI:MGI:1919148
See related: Ensembl:ENSMUSG00000068246 AllianceGenome:MGI:1919148
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310016F22Rik
Summary: Predicted to enable chloride channel activity and lipid binding activity. Predicted to be located in extracellular space. Predicted to be part of high-density lipoprotein particle and very-low-density lipoprotein particle. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human APOL1 (apolipoprotein L1) and APOL2 (apolipoprotein L2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 51.5), small intestine adult (RPKM 29.9) and 2 other tissues See more
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Genomic context

Location:: 15 E1; 15 36.75 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (77613248..77620582)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (77729047..77736382)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors identified a new antiviral protein induced by interferon, ApoL9b, whose lack of expression in primary neurons likely contributes to the high sensitivity of these cells to viral infection.
Title: Inefficient type I interferon-mediated antiviral protection of primary mouse neurons is associated with the lack of apolipoprotein l9 expression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein L 9b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168660.1 → NP_001162131.1 apolipoprotein L 9b

See identical proteins and their annotated locations for NP_001162131.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.

Source sequence(s)

AK009386, BF148017

Consensus CDS

CCDS27604.1

UniProtKB/TrEMBL

D3Z501, Q6PF90, Q8C7I4

Related

ENSMUSP00000105397.3, ENSMUST00000109775.4

Conserved Domains (1) summary

pfam05461
Location:1 → 310

ApoL; Apolipoprotein L
NM_173743.4 → NP_776104.1 apolipoprotein L 9b

See identical proteins and their annotated locations for NP_776104.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site and segment for its 5' UTR compared to variant 1. Both variants encode the same protein.

Source sequence(s)

AK050167, BF148017

Consensus CDS

CCDS27604.1

UniProtKB/TrEMBL

D3Z501, Q6PF90, Q8C7I4

Related

ENSMUSP00000155314.2, ENSMUST00000230979.2

Conserved Domains (1) summary

pfam05461
Location:1 → 310

ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

77613248..77620582

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248781.2 → XP_030104641.1 apolipoprotein L 9b isoform X1

UniProtKB/TrEMBL

D3Z501, Q6PF90, Q8C7I4

Conserved Domains (1) summary

pfam05461
Location:1 → 310

ApoL; Apolipoprotein L