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    Efcab8 EF-hand calcium binding domain 8 [ Mus musculus (house mouse) ]

    Gene ID: 100504221, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Efcab8provided by MGI
    Official Full Name
    EF-hand calcium binding domain 8provided by MGI
    Primary source
    MGI:MGI:3644206
    See related
    Ensembl:ENSMUSG00000044083 AllianceGenome:MGI:3644206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm38434; EG329541; A630008I04
    Summary
    Predicted to enable calcium ion binding activity. Orthologous to human EFCAB8 (EF-hand calcium binding domain 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 6.1) See more
    Orthologs
    human all
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    Genomic context

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    See Efcab8 in Genome Data Viewer
    Location:
    2; 2 H1
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (153615231..153686672)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153773311..153844752)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 3B Neighboring gene DNA methyltransferase 3C Neighboring gene sorting nexin 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3413 Neighboring gene microtubule-associated protein, RP/EB family, member 1 Neighboring gene translocase of outer mitochondrial membrane 20 homolog pseudogene Neighboring gene Sad1 and UNC84 domain containing 5 Neighboring gene BPI fold containing family B, member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC178411

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    eF-hand calcium-binding domain-containing protein 8
    Names
    EF-hand calcium-binding domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370916.1 → NP_001357845.1  eF-hand calcium-binding domain-containing protein 8

      Status: VALIDATED

      Source sequence(s)
      AL833803
      Consensus CDS
      CCDS89569.1
      UniProtKB/TrEMBL
      H3BL58
      Related
      ENSMUSP00000135661.3, ENSMUST00000126656.4
      Conserved Domains (4) summary
      COG2319
      Location:190 → 511
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:432 → 470
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:126 → 175
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:381 → 673
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      153615231..153686672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246361.1 → XP_030102221.1  eF-hand calcium-binding domain-containing protein 8 isoform X10

      Conserved Domains (4) summary
      COG2319
      Location:190 → 511
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:385 → 428
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:126 → 175
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:381 → 673
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_030246358.2 → XP_030102218.1  eF-hand calcium-binding domain-containing protein 8 isoform X9

      Conserved Domains (4) summary
      COG2319
      Location:190 → 511
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:385 → 428
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:126 → 175
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:381 → 673
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_030246363.2 → XP_030102223.1  eF-hand calcium-binding domain-containing protein 8 isoform X11

      Conserved Domains (4) summary
      COG2319
      Location:190 → 511
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:385 → 428
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:126 → 175
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:381 → 647
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_030246332.2 → XP_030102192.1  eF-hand calcium-binding domain-containing protein 8 isoform X2

      Conserved Domains (4) summary
      COG2319
      Location:190 → 511
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:432 → 470
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:126 → 175
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:381 → 673
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_030246328.2 → XP_030102188.1  eF-hand calcium-binding domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      H3BL58
      Conserved Domains (4) summary
      COG2319
      Location:190 → 511
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:432 → 470
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:126 → 175
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:381 → 673
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_030246333.2 → XP_030102193.1  eF-hand calcium-binding domain-containing protein 8 isoform X3

      Conserved Domains (4) summary
      COG2319
      Location:828 → 995
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:432 → 470
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:126 → 175
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:381 → 609
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_030246331.2 → XP_030102191.1  eF-hand calcium-binding domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      H3BL58
      Conserved Domains (4) summary
      COG2319
      Location:190 → 511
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:432 → 470
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:126 → 175
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:381 → 673
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_030246347.2 → XP_030102207.1  eF-hand calcium-binding domain-containing protein 8 isoform X5

      Conserved Domains (4) summary
      COG2319
      Location:752 → 919
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:263 → 301
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:126 → 175
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:381 → 625
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    9. XM_030246334.2 → XP_030102194.1  eF-hand calcium-binding domain-containing protein 8 isoform X4

      Conserved Domains (4) summary
      COG2319
      Location:131 → 452
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:373 → 411
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:67 → 116
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:322 → 614
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. XM_030246335.2 → XP_030102195.1  eF-hand calcium-binding domain-containing protein 8 isoform X4

      Conserved Domains (4) summary
      COG2319
      Location:131 → 452
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:373 → 411
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:67 → 116
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:322 → 614
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    11. XM_030246340.2 → XP_030102200.1  eF-hand calcium-binding domain-containing protein 8 isoform X4

      Conserved Domains (4) summary
      COG2319
      Location:131 → 452
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:373 → 411
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:67 → 116
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:322 → 614
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    12. XM_030246342.2 → XP_030102202.1  eF-hand calcium-binding domain-containing protein 8 isoform X4

      Conserved Domains (4) summary
      COG2319
      Location:131 → 452
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:373 → 411
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:67 → 116
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:322 → 614
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    13. XM_030246344.2 → XP_030102204.1  eF-hand calcium-binding domain-containing protein 8 isoform X4

      Conserved Domains (4) summary
      COG2319
      Location:131 → 452
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:373 → 411
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:67 → 116
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:322 → 614
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    14. XM_030246343.1 → XP_030102203.1  eF-hand calcium-binding domain-containing protein 8 isoform X4

      Conserved Domains (4) summary
      COG2319
      Location:131 → 452
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:373 → 411
      7WD40; WD40 repeat [structural motif]
      pfam13833
      Location:67 → 116
      EF-hand_8; EF-hand domain pair
      cl29593
      Location:322 → 614
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    15. XM_030246348.2 → XP_030102208.1  eF-hand calcium-binding domain-containing protein 8 isoform X6

      Conserved Domains (3) summary
      COG2319
      Location:29 → 350
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:271 → 309
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:220 → 512
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    16. XM_036157054.1 → XP_036012947.1  eF-hand calcium-binding domain-containing protein 8 isoform X7

      Conserved Domains (4) summary
      COG2319
      Location:30 → 330
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:251 → 289
      7WD40; WD40 repeat [structural motif]
      cd21577
      Location:1051 → 1109
      KLF3_N; N-terminal domain of Kruppel-like factor 3
      cl29593
      Location:200 → 492
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    17. XM_006500526.3 → XP_006500589.1  eF-hand calcium-binding domain-containing protein 8 isoform X8

      Conserved Domains (2) summary
      COG2319
      Location:66 → 228
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:103 → 138
      7WD40; WD40 repeat [structural motif]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177849.3: Suppressed sequence

      Description
      NM_177849.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NR_036629.1: Suppressed sequence

      Description
      NR_036629.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C9R9.1 GenPept UniProtKB/Swiss-Prot:Q8C9R9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials