Trp53bp1 transformation related protein 53 binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trp53bp1provided by MGI
Official Full Name: transformation related protein 53 binding protein 1provided by MGI
Primary source: MGI:MGI:1351320
See related: Ensembl:ENSMUSG00000043909 AllianceGenome:MGI:1351320
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 53BP1; m53BP1; p53BP1; Tp53bp1
Summary: Enables damaged DNA binding activity; methylated histone binding activity; and telomeric DNA binding activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and positive regulation of isotype switching. Acts upstream of or within DNA repair. Located in chromosome and nuclear body. Part of DNA repair complex. Is expressed in several structures, including ileum; liver; lung; nervous system; and sensory organ. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E14 (RPKM 21.5), whole brain E14.5 (RPKM 20.5) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.37 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (121025316..121126830, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (121194835..121296354, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATM and 53BP1 regulate alternative end joining-mediated V(D)J recombination.
Title: ATM and 53BP1 regulate alternative end joining-mediated V(D)J recombination.
PTEN-mediated dephosphorylation of 53BP1 confers cellular resistance to DNA damage in cancer cells.
Title: PTEN-mediated dephosphorylation of 53BP1 confers cellular resistance to DNA damage in cancer cells.
DNA repair and antibody diversification: the 53BP1 paradigm.
Title: DNA repair and antibody diversification: the 53BP1 paradigm.
Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps.
Title: Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps.
53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice.
Title: 53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice.
betaarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1.
Title: βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1.
Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway.
Title: Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway.
Considering Cell Proliferation to Optimize Detection of Radiation-Induced 53BP1 Positive Foci in 15 Mouse Strains Ex Vivo.
Title: Considering Cell Proliferation to Optimize Detection of Radiation-Induced 53BP1 Positive Foci in 15 Mouse Strains Ex Vivo.
Inverse dose-rate effect of ionising radiation on residual 53BP1 foci in the eye lens.
Title: Inverse dose-rate effect of ionising radiation on residual 53BP1 foci in the eye lens.
53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function.
Title: 53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function.

Submit: New GeneRIF Correction See all GeneRIFs (66)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (6)
Endonuclease-mediated (7) 1 citation
Gene trapped (1) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234509

RH44505 (e-PCR)
- UniSTS:74295

RH139947 (e-PCR)
- UniSTS:222030

MARC_10287-10288:998927046:1 (e-PCR)
- UniSTS:267098

RH68009 (e-PCR)
- UniSTS:18818

RH127268 (e-PCR)
- UniSTS:167319

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone reader activity	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables p53 binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	TAS Traceable Author Statement more info	PubMed
enables ubiquitin-modified histone reader activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-modified histone reader activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info	PubMed
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to X-ray	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via classical nonhomologous end joining	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via classical nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via nonhomologous end joining	IDA Inferred from Direct Assay more info	PubMed
involved_in double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via homologous recombination	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of isotype switching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of isotype switching	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to site of double-strand break	IEA Inferred from Electronic Annotation more info
involved_in protein localization to site of double-strand break	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of DNA repair complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in replication fork	IDA Inferred from Direct Assay more info	PubMed
located_in site of double-strand break	IDA Inferred from Direct Assay more info	PubMed
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TP53-binding protein 1

Names: murine p53-binding protein; p53-binding protein 1; tumor suppressor p53-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290830.2 → NP_001277759.1 TP53-binding protein 1 isoform b

See identical proteins and their annotated locations for NP_001277759.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AL929059

Consensus CDS

CCDS71125.1

UniProtKB/TrEMBL

A0A5H1ZRL7

Related

ENSMUSP00000106277.2, ENSMUST00000110647.8

Conserved Domains (4) summary

COG5271
Location:563 → 890

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1675 → 1786

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1431 → 1551

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1814 → 1917

BRCT_3; BRCA1 C Terminus (BRCT) domain
NM_001421437.1 → NP_001408366.1 TP53-binding protein 1 isoform c

Status: VALIDATED

Source sequence(s)

AL929059
NM_001421438.1 → NP_001408367.1 TP53-binding protein 1 isoform d

Status: VALIDATED

Source sequence(s)

AL929059
NM_001421439.1 → NP_001408368.1 TP53-binding protein 1 isoform e

Status: VALIDATED

Source sequence(s)

AL929059
NM_001421440.1 → NP_001408369.1 TP53-binding protein 1 isoform f

Status: VALIDATED

Source sequence(s)

AL929059
NM_001421441.1 → NP_001408370.1 TP53-binding protein 1 isoform g

Status: VALIDATED

Source sequence(s)

AL929059
NM_013735.5 → NP_038763.3 TP53-binding protein 1 isoform a

See identical proteins and their annotated locations for NP_038763.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AL929059

Consensus CDS

CCDS50684.1

UniProtKB/Swiss-Prot

A2AU89, A2AU91, P70399, Q68FD0, Q8CI97, Q91YC9

Related

ENSMUSP00000106278.2, ENSMUST00000110648.8

Conserved Domains (4) summary

COG5271
Location:563 → 890

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1725 → 1836

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1481 → 1601

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1864 → 1967

BRCT_3; BRCA1 C Terminus (BRCT) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

121025316..121126830 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251686.2 → XP_030107546.1 TP53-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

A2AU89, A2AU91, P70399, Q68FD0, Q8CI97, Q91YC9

Conserved Domains (4) summary

COG5271
Location:563 → 890

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1725 → 1836

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1481 → 1601

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1864 → 1967

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_036162270.1 → XP_036018163.1 TP53-binding protein 1 isoform X13

Conserved Domains (4) summary

COG5271
Location:333 → 792

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1453 → 1564

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1211 → 1331

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1592 → 1695

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_017318937.3 → XP_017174426.1 TP53-binding protein 1 isoform X11

Conserved Domains (4) summary

COG5271
Location:563 → 1022

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1635 → 1746

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1391 → 1511

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1774 → 1877

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_017318936.3 → XP_017174425.1 TP53-binding protein 1 isoform X7

Conserved Domains (4) summary

COG5271
Location:563 → 1022

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1683 → 1794

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1441 → 1561

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1822 → 1925

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_036162266.1 → XP_036018159.1 TP53-binding protein 1 isoform X5

Conserved Domains (4) summary

COG5271
Location:563 → 890

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1692 → 1803

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1450 → 1570

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1831 → 1934

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_036162267.1 → XP_036018160.1 TP53-binding protein 1 isoform X9

Conserved Domains (4) summary

COG5271
Location:563 → 890

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1673 → 1784

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1431 → 1551

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1812 → 1915

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_011239584.4 → XP_011237886.1 TP53-binding protein 1 isoform X8

See identical proteins and their annotated locations for XP_011237886.1

UniProtKB/TrEMBL

A0A5H1ZRL7

Conserved Domains (4) summary

COG5271
Location:563 → 890

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1675 → 1786

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1431 → 1551

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1814 → 1917

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_006499661.5 → XP_006499724.1 TP53-binding protein 1 isoform X2

Conserved Domains (4) summary

COG5271
Location:563 → 890

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1723 → 1834

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1481 → 1601

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1862 → 1965

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_011239581.4 → XP_011237883.1 TP53-binding protein 1 isoform X1

See identical proteins and their annotated locations for XP_011237883.1

UniProtKB/Swiss-Prot

A2AU89, A2AU91, P70399, Q68FD0, Q8CI97, Q91YC9

Conserved Domains (4) summary

COG5271
Location:563 → 890

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1725 → 1836

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1481 → 1601

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1864 → 1967

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_030251685.2 → XP_030107545.1 TP53-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

A2AU89, A2AU91, P70399, Q68FD0, Q8CI97, Q91YC9

Conserved Domains (4) summary

COG5271
Location:563 → 890

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1725 → 1836

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1481 → 1601

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1864 → 1967

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_036162268.1 → XP_036018161.1 TP53-binding protein 1 isoform X10

Conserved Domains (4) summary

COG5271
Location:491 → 818

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1653 → 1764

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1409 → 1529

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1792 → 1895

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_036162269.1 → XP_036018162.1 TP53-binding protein 1 isoform X12

Conserved Domains (4) summary

COG5271
Location:333 → 660

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1495 → 1606

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1251 → 1371

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1634 → 1737

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_030251687.2 → XP_030107547.1 TP53-binding protein 1 isoform X12

Conserved Domains (4) summary

COG5271
Location:333 → 660

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1495 → 1606

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1251 → 1371

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1634 → 1737

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_011239583.4 → XP_011237885.1 TP53-binding protein 1 isoform X6

Conserved Domains (4) summary

COG5271
Location:563 → 1022

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1685 → 1796

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1441 → 1561

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1824 → 1927

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_011239582.4 → XP_011237884.1 TP53-binding protein 1 isoform X4

Conserved Domains (4) summary

COG5271
Location:563 → 890

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1694 → 1805

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1450 → 1570

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1833 → 1936

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_030251688.1 → XP_030107548.1 TP53-binding protein 1 isoform X14

Conserved Domains (4) summary

COG5271
Location:170 → 497

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1332 → 1443

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1088 → 1208

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1471 → 1574

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_006499662.5 → XP_006499725.1 TP53-binding protein 1 isoform X3

Conserved Domains (4) summary

COG5271
Location:558 → 885

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd17745
Location:1720 → 1831

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1476 → 1596

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1859 → 1962

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_006499668.5 → XP_006499731.1 TP53-binding protein 1 isoform X16

Conserved Domains (3) summary

cd17745
Location:776 → 887

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:532 → 652

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:915 → 1018

BRCT_3; BRCA1 C Terminus (BRCT) domain
XM_011239585.4 → XP_011237887.1 TP53-binding protein 1 isoform X15

UniProtKB/TrEMBL

A2AU90

Related

ENSMUSP00000114457.2, ENSMUST00000131245.2