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    Zmym4 zinc finger, MYM-type 4 [ Mus musculus (house mouse) ]

    Gene ID: 67785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zmym4provided by MGI
    Official Full Name
    zinc finger, MYM-type 4provided by MGI
    Primary source
    MGI:MGI:1915035
    See related
    Ensembl:ENSMUSG00000042446 AllianceGenome:MGI:1915035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MYM; CDIR; Zfp262; Znf262; mKIAA0425; D630001M21; 6330503C17Rik
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in cytoskeleton organization and regulation of cell morphogenesis. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina nuclear layer; and thyroid gland. Orthologous to human ZMYM4 (zinc finger MYM-type containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 10.4), whole brain E14.5 (RPKM 8.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zmym4 in Genome Data Viewer
    Location:
    4 D2.2; 4 61.05 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126755612..126862021, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126861819..126969377, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AU040320 Neighboring gene predicted gene, 24161 Neighboring gene STARR-positive B cell enhancer ABC_E4667 Neighboring gene predicted gene, 25604 Neighboring gene STARR-seq mESC enhancer starr_11411 Neighboring gene STARR-positive B cell enhancer ABC_E7989 Neighboring gene STARR-seq mESC enhancer starr_11413 Neighboring gene STARR-seq mESC enhancer starr_11417 Neighboring gene STARR-seq mESC enhancer starr_11418 Neighboring gene splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene zinc finger, MYM domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. Marenne G, et al. Cell Metab, 2020 Jun 2. PMID 32492392, Free PMC Article
    2. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351
    3. An Oct4-centered protein interaction network in embryonic stem cells. van den Berg DLC, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362541, Free PMC Article
    4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger MYM-type protein 4
    Names
    cell death inhibiting RNA
    zinc finger protein 262

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114399.2 → NP_001107871.1  zinc finger MYM-type protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001107871.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL606908, AL606985
      Consensus CDS
      CCDS51303.1
      UniProtKB/Swiss-Prot
      A2A791, Q3UFQ2, Q6ZQB9, Q80X47, Q8K1H5
      Related
      ENSMUSP00000101714.3, ENSMUST00000106108.9
      Conserved Domains (3) summary
      smart00746
      Location:389 → 429
      TRASH; metallochaperone-like domain
      pfam06467
      Location:478 → 521
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1357 → 1526
      DUF3504; Domain of unknown function (DUF3504)

    2. NM_001357201.2 → NP_001344130.1  zinc finger MYM-type protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606908, AL606985
      UniProtKB/TrEMBL
      F6VYE2
      Conserved Domains (2) summary
      pfam06467
      Location:481 → 521
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1267 → 1436
      DUF3504; Domain of unknown function (DUF3504)

    3. NM_001379530.1 → NP_001366459.1  zinc finger MYM-type protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606908, AL606985
      Conserved Domains (3) summary
      smart00746
      Location:389 → 429
      TRASH; metallochaperone-like domain
      pfam06467
      Location:481 → 521
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1356 → 1526
      DUF3504; Domain of unknown function (DUF3504)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      126755612..126862021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503344.5 → XP_006503407.1  zinc finger MYM-type protein 4 isoform X1

      UniProtKB/TrEMBL
      F6VYE2
      Related
      ENSMUSP00000120813.2, ENSMUST00000135003.2
      Conserved Domains (2) summary
      pfam06467
      Location:481 → 521
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1274 → 1438
      DUF3504; Domain of unknown function (DUF3504)

    2. XM_030253729.1 → XP_030109589.1  zinc finger MYM-type protein 4 isoform X2

      Conserved Domains (3) summary
      smart00746
      Location:500 → 538
      TRASH; metallochaperone-like domain
      pfam06467
      Location:450 → 490
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1332 → 1496
      DUF3504; Domain of unknown function (DUF3504)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A791.1 GenPept UniProtKB/Swiss-Prot:A2A791

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