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    Nhsl2 NHS like 2 [ Mus musculus (house mouse) ]

    Gene ID: 100042480, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nhsl2provided by MGI
    Official Full Name
    NHS like 2provided by MGI
    Primary source
    MGI:MGI:3645090
    See related
    Ensembl:ENSMUSG00000079481 AllianceGenome:MGI:3645090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm10456; EG621083; 6430511F03; 1110062M06Rik
    Summary
    Predicted to be involved in cell differentiation. Orthologous to human NHSL2 (NHS like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 2.1), bladder adult (RPKM 1.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nhsl2 in Genome Data Viewer
    Location:
    X D; X 44.75 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100892942..101135661)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101849261..102092055)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene H3.3 histone A, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_47663 Neighboring gene predicted gene 3858 Neighboring gene STARR-seq mESC enhancer starr_47664 Neighboring gene predicted gene, 25828 Neighboring gene STARR-seq mESC enhancer starr_47665 Neighboring gene STARR-seq mESC enhancer starr_47666 Neighboring gene retrotransposon Gag like 5 Neighboring gene STARR-positive B cell enhancer ABC_E5732 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    2. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    NHS-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163610.2 → NP_001157082.1  NHS-like protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL807784, AL808026
      Consensus CDS
      CCDS53156.1
      UniProtKB/Swiss-Prot
      B1AXH1, E9Q0V6
      Related
      ENSMUSP00000098893.5, ENSMUST00000101339.8
      Conserved Domains (1) summary
      pfam15273
      Location:623 → 755
      NHS; NHS-like

    2. NM_001406043.1 → NP_001392972.1  NHS-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL807784, AL808026

    3. NM_001406044.1 → NP_001392973.1  NHS-like protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL807784, AL808026

    4. NM_001406045.1 → NP_001392974.1  NHS-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL807784, AL808026

    5. NM_001406046.1 → NP_001392975.1  NHS-like protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL807784, AL808026

    6. NM_001406047.1 → NP_001392976.1  NHS-like protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL807784, AL808026

    7. NM_001406048.1 → NP_001392977.1  NHS-like protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL807784, AL808026

    8. NM_001406049.1 → NP_001392978.1  NHS-like protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL807784, AL808026

    9. NM_001406050.1 → NP_001392979.1  NHS-like protein 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL807784, AL808026

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      100892942..101135661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247499.3 → XP_011245801.1  NHS-like protein 2 isoform X2

      Conserved Domains (1) summary
      pfam15273
      Location:646 → 801
      NHS; NHS-like

    2. XM_030251165.2 → XP_030107025.1  NHS-like protein 2 isoform X17

      Conserved Domains (1) summary
      pfam15273
      Location:258 → 413
      NHS; NHS-like

    3. XM_006527718.5 → XP_006527781.1  NHS-like protein 2 isoform X3

      Conserved Domains (1) summary
      pfam15273
      Location:553 → 708
      NHS; NHS-like

    4. XM_006527727.5 → XP_006527790.1  NHS-like protein 2 isoform X14

      Conserved Domains (1) summary
      pfam15273
      Location:371 → 505
      NHS; NHS-like

    5. XM_006527720.5 → XP_006527783.1  NHS-like protein 2 isoform X5

      Conserved Domains (1) summary
      pfam15273
      Location:544 → 699
      NHS; NHS-like

    6. XM_030251164.2 → XP_030107024.1  NHS-like protein 2 isoform X10

      Conserved Domains (1) summary
      pfam15273
      Location:437 → 592
      NHS; NHS-like

    7. XM_036161746.1 → XP_036017639.1  NHS-like protein 2 isoform X15

    8. XM_006527721.5 → XP_006527784.1  NHS-like protein 2 isoform X6

      See identical proteins and their annotated locations for XP_006527784.1

      Conserved Domains (1) summary
      pfam15273
      Location:539 → 694
      NHS; NHS-like

    9. XM_036161747.1 → XP_036017640.1  NHS-like protein 2 isoform X17

      Conserved Domains (1) summary
      pfam15273
      Location:258 → 413
      NHS; NHS-like

    10. XM_030251161.2 → XP_030107021.1  NHS-like protein 2 isoform X1

      Conserved Domains (1) summary
      pfam15273
      Location:658 → 813
      NHS; NHS-like

    11. XM_030251162.2 → XP_030107022.1  NHS-like protein 2 isoform X4

      Conserved Domains (1) summary
      pfam15273
      Location:551 → 706
      NHS; NHS-like

    12. XM_030251163.2 → XP_030107023.1  NHS-like protein 2 isoform X7

      Conserved Domains (1) summary
      pfam15273
      Location:507 → 662
      NHS; NHS-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AXH1.2 GenPept UniProtKB/Swiss-Prot:B1AXH1

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