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Links from Protein

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    ftn-2 Ferritin [ Caenorhabditis elegans ]

    Gene ID: 171934, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ftn-2
    Official Full Name
    Ferritin
    Primary source
    WormBase:WBGene00001501
    Locus tag
    CELE_D1037.3
    See related
    AllianceGenome:WB:WBGene00001501
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables identical protein binding activity. Involved in defense response to Gram-positive bacterium. Predicted to be active in cytoplasm. Is expressed in body wall musculature; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in basal ganglia disease; hemochromatosis type 5; hyperferritinemia-cataract syndrome; and neurodegenerative disease (multiple). Orthologous to several human genes including FTMT (ferritin mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ftn-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (3680180..3680927, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DEgenerin Like Neighboring gene Sema domain-containing protein Neighboring gene Ras-related protein Rab-8A Neighboring gene Protein SON Neighboring gene phospholipase A2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative proteomics identifies ferritin in the innate immune response of C. elegans. Simonsen KT, et al. Virulence, 2011 Mar-Apr. PMID 21389771
    2. Transparent worms help survey the fortress of innate immunity. Irazoqui JE. Virulence, 2011 Mar-Apr. PMID 21460640
    3. Biochemical Characterization of Caenorhabditis elegans Ferritins. Mubarak SSM, et al. Biochemistry, 2023 May 2. PMID 37014173
    4. Disruption of iron homeostasis increases phosphine toxicity in Caenorhabditis elegans. Cha'on U, et al. Toxicol Sci, 2007 Mar. PMID 17175555
    5. TOR functions as a molecular switch connecting an iron cue with host innate defense against bacterial infection. Ma YC, et al. PLoS Genet, 2021 Mar. PMID 33657091, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric iron binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ferritin
    NP_491198.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3680180..3680927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058797.9 → NP_491198.1  Ferritin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491198.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TYS3
      Conserved Domains (2) summary
      cd01056
      Location:9 → 166
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:13 → 154
      Ferritin; Ferritin-like domain
    Nucleotide Protein
    Heading Accession and Version

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