drsh-1 Ribonuclease 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: drsh-1
Official Full Name: Ribonuclease 3
Primary source: WormBase:WBGene00009163
Locus tag: CELE_F26E4.10
See related: AllianceGenome:WB:WBGene00009163
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ribonuclease III activity. Involved in primary miRNA processing and sexual reproduction. Predicted to be part of microprocessor complex. Predicted to be active in nucleus. Orthologous to human DROSHA (drosha ribonuclease III). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See drsh-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (9781324..9785724, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that components of the miRNA machinery, especially the miRNA-processing enzyme DRSH-1, play an important role in mediating IF-induced longevity via the regulation of fasting-induced changes in gene expression.
Title: The microRNA machinery regulates fasting-induced changes in gene expression and longevity in Caenorhabditis elegans.
role for pash-1 in miRNA maturation and miRNA-mediated gene regulation.
Title: Processing of primary microRNAs by the Microprocessor complex.
cleavage is catalysed by Drosha, a nuclease of the RNase III family, which acts on primary miRNA transcripts (pri-miRNAs) in the nucleus
Title: Processing of primary microRNAs by the Microprocessor complex.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F26E4.10 (e-PCR)
- UniSTS:321408

F26E4.13 (e-PCR)
- UniSTS:321409

F26E4.8 (e-PCR)
- UniSTS:309964

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ribonuclease III activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonuclease III activity	IEA Inferred from Electronic Annotation more info
enables ribonuclease III activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in gonadal mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in miRNA processing	IEA Inferred from Electronic Annotation more info
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in primary miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in primary miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in sexual reproduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of microprocessor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of microprocessor complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ribonuclease 3

NP_001122460.2

Confirmed by transcript evidence

NP_492599.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9781324..9785724 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001128988.5 → NP_001122460.2 Ribonuclease 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122460.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O01326

Conserved Domains (3) summary

smart00535
Location:846 → 974

RIBOc; Ribonuclease III family

smart00358
Location:983 → 1056

DSRM; Double-stranded RNA binding motif

PRK00102
Location:831 → 1056

rnc; ribonuclease III; Reviewed
NM_060198.5 → NP_492599.1 Ribonuclease 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492599.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8WI03, O01326, O01327, Q9U9Q8

Conserved Domains (3) summary

smart00535
Location:848 → 976

RIBOc; Ribonuclease III family

smart00358
Location:985 → 1058

DSRM; Double-stranded RNA binding motif

PRK00102
Location:833 → 1058

rnc; ribonuclease III; Reviewed