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    dpy-5 Cuticle collagen dpy-5 [ Caenorhabditis elegans ]

    Gene ID: 172197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpy-5
    Official Full Name
    Cuticle collagen dpy-5
    Primary source
    WormBase:WBGene00001067
    Locus tag
    CELE_F27C1.8
    See related
    AllianceGenome:WB:WBGene00001067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    A structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and post-embryonic body morphogenesis. Located in collagen and cuticulin-based cuticle extracellular matrix. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dpy-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003279.8 (5432197..5433051, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Copper transport protein Neighboring gene ncRNA Neighboring gene Doublecortin domain-containing protein Neighboring gene Ovule protein Neighboring gene Doublecortin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fine structure of the Caenorhabditis elegans secretory-excretory system. Nelson FK, et al. J Ultrastruct Res, 1983 Feb. PMID 6827646
    2. Meiotic pairing behavior of two free duplications of linkage group I in Caenorhabditis elegans. Rose AM, et al. Mol Gen Genet, 1984. PMID 6593563
    3. Analysis of nematode mechanics by piezoresistive displacement clamp. Park SJ, et al. Proc Natl Acad Sci U S A, 2007 Oct 30. PMID 17962419, Free PMC Article
    4. Caenorhabditis elegans dpy-5 is a cuticle procollagen processed by a proprotein convertase. Thacker C, et al. Cell Mol Life Sci, 2006 May. PMID 16649143, Free PMC Article
    5. The bodies of dpy-10(e128) are twice as stiff as wild type. Fechner S, et al. MicroPubl Biol, 2018 Aug 6. PMID 32550396, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Several lesions in the dpy-5 gene which encodes a predicted cuticle procollagen is described.
      Title: Caenorhabditis elegans dpy-5 is a cuticle procollagen processed by a proprotein convertase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of collagen and cuticulin-based cuticle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen and cuticulin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen and cuticulin-based cuticle extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cuticle collagen dpy-5
    NP_491595.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5432197..5433051 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059194.6 → NP_491595.1  Cuticle collagen dpy-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491595.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91285
      Conserved Domains (2) summary
      pfam01391
      Location:207 → 263
      Collagen; Collagen triple helix repeat (20 copies)
      smart01088
      Location:5 → 56
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91285.1

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