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    goa-1 Guanine nucleotide-binding protein G(o) subunit alpha [ Caenorhabditis elegans ]

    Gene ID: 172505, updated on 2-Nov-2024

    Summary

    Official Symbol
    goa-1
    Official Full Name
    Guanine nucleotide-binding protein G(o) subunit alpha
    Primary source
    WormBase:WBGene00001648
    Locus tag
    CELE_C26C6.2
    See related
    AllianceGenome:WB:WBGene00001648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables several functions, including G protein activity; G protein-coupled acetylcholine receptor activity; and GTP binding activity. Involved in several processes, including G protein-coupled dopamine receptor signaling pathway; detection of cold stimulus involved in thermoception; and response to serotonin. Located in cell cortex. Is expressed in several structures, including neurons; non-striated muscle; pharynx; spermatheca; and vulva. Used to study developmental and epileptic encephalopathy and early infantile epileptic encephalopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See goa-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (7522116..7526716)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase nas-36 Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene Transcription factor dcp-66

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled acetylcholine receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables G protein-coupled acetylcholine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-membrane adaptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-negative bacterium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in detection of cold stimulus involved in thermoception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of synaptic transmission, cholinergic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of nematode pharyngeal pumping IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to food IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to serotonin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Guanine nucleotide-binding protein G(o) subunit alpha
    NP_492108.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7522116..7526716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059707.6NP_492108.1  Guanine nucleotide-binding protein G(o) subunit alpha [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492108.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P51875, Q18205
      Conserved Domains (2) summary
      cd00066
      Location:34348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:14352
      G_alpha; G protein alpha subunit