asah-1 Acid ceramidase subunit beta [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: asah-1
Official Full Name: Acid ceramidase subunit beta
Primary source: WormBase:WBGene00010769
Locus tag: CELE_K11D2.2
See related: AllianceGenome:WB:WBGene00010769
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable N-acylsphingosine amidohydrolase activity. Predicted to be involved in fatty acid metabolic process and sphingolipid metabolic process. Predicted to be located in extracellular region and lysosome. Is expressed in intestine. Human ortholog(s) of this gene implicated in Farber lipogranulomatosis; sphingolipidosis; and spinal muscular atrophy with progressive myoclonic epilepsy. Orthologous to human ASAH1 (N-acylsphingosine amidohydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See asah-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (12505114..12507569)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K11D2.2 (e-PCR)
- UniSTS:307807

K11D2.1 (e-PCR)
- UniSTS:316062

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables N-acylsphingosine amidohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acylsphingosine amidohydrolase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid amide hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Acid ceramidase subunit beta

NP_493173.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

12505114..12507569

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060772.11 → NP_493173.1 Acid ceramidase subunit beta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493173.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45686

Conserved Domains (2) summary

cd01903
Location:131 → 376

Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...

pfam15508
Location:45 → 105

NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase