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    MERTK MER proto-oncogene, tyrosine kinase [ Gorilla gorilla gorilla (western lowland gorilla) ]

    Gene ID: 101126479, updated on 3-Dec-2024

    Summary

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    Gene symbol
    MERTK
    Gene description
    MER proto-oncogene, tyrosine kinase
    See related
    Ensembl:ENSGGOG00000013806
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gorilla gorilla gorilla (sub-species: gorilla)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Gorilla
    Orthologs
    human mouse all
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    Genomic context

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    See MERTK in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mGorGor1-v2.0_pri (GCF_029281585.2) 12 NC_073236.2 (49515901..49649467)
    RS_2023_04 previous assembly NHGRI_mGorGor1-v1.1-0.2.freeze_pri (GCF_029281585.1) 2A NC_073225.1 (97568516..97700150, complement)

    Chromosome 12 - NC_073236.2Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 1 Neighboring gene eukaryotic translation elongation factor 1 epsilon-1-like Neighboring gene RNA transcription, translation and transport factor protein-like Neighboring gene zinc transporter 6-like Neighboring gene transmembrane protein 87B Neighboring gene fibulin 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase Mer

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_029281585.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mGorGor1-v2.0_pri Primary Assembly

    Genomic

    1. NC_073236.2 Reference NHGRI_mGorGor1-v2.0_pri Primary Assembly

      Range
      49515901..49649467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031008269.3 → XP_030864129.1  tyrosine-protein kinase Mer isoform X1

      UniProtKB/TrEMBL
      G3RD78
      Conserved Domains (4) summary
      cd05749
      Location:199 → 279
      Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
      cd00063
      Location:284 → 378
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14204
      Location:579 → 862
      PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
      cd00096
      Location:111 → 182
      Ig; Immunoglobulin domain

    2. XM_055378291.2 → XP_055234266.1  tyrosine-protein kinase Mer isoform X2

      UniProtKB/TrEMBL
      A0A2I2Z4H8
    Nucleotide Protein
    Heading Accession and Version

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