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    ufd-3 PUL domain-containing protein;Ubiquitin fusion degradation protein 3 homolog [ Caenorhabditis elegans ]

    Gene ID: 3565222, updated on 9-Dec-2024

    Summary

    Official Symbol
    ufd-3
    Official Full Name
    PUL domain-containing protein;Ubiquitin fusion degradation protein 3 homolog
    Primary source
    WormBase:WBGene00007333
    Locus tag
    CELE_C05C10.6
    See related
    AllianceGenome:WB:WBGene00007333
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and ubiquitin recycling. Located in cytoplasm. Is expressed in intestine and nervous system. Orthologous to human PLAA (phospholipase A2 activating protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ufd-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (9940753..9944107)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Cytochrome P450;USH2A;Uncharacterized protein Neighboring gene FAD synthase;Molybdenum cofactor biosynthesis protein-like region Neighboring gene Zinc finger protein egl-43 Neighboring gene Thymidylate kinase

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    PUL domain-containing protein;Ubiquitin fusion degradation protein 3 homolog
    NP_001254232.1
    • Confirmed by transcript evidence
    NP_496146.1
    • Confirmed by transcript evidence
    NP_496147.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9940753..9944107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063746.5NP_496147.1  Ubiquitin fusion degradation protein 3 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496147.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFK5
      Conserved Domains (5) summary
      COG2319
      Location:23275
      WD40; WD40 repeat [General function prediction only]
      pfam08324
      Location:587836
      PUL; PUL domain
      pfam09070
      Location:420472
      PFU; PFU (PLAA family ubiquitin binding)
      sd00039
      Location:77115
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:22318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_063745.4NP_496146.1  Ubiquitin fusion degradation protein 3 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496146.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EES6, G5EFK5
      Conserved Domains (4) summary
      sd00039
      Location:77115
      7WD40; WD40 repeat [structural motif]
      pfam08324
      Location:589838
      PUL; PUL domain
      pfam09070
      Location:422474
      PFU; PFU (PLAA family ubiquitin binding)
      cl25539
      Location:22320
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001267303.3NP_001254232.1  PUL domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254232.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HAD6
      Conserved Domains (1) summary
      pfam08324
      Location:4201
      PUL; PUL domain