ufd-3 PUL domain-containing protein;Ubiquitin fusion degradation protein 3 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ufd-3
Official Full Name: PUL domain-containing protein;Ubiquitin fusion degradation protein 3 homolog
Primary source: WormBase:WBGene00007333
Locus tag: CELE_C05C10.6
See related: AllianceGenome:WB:WBGene00007333
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and ubiquitin recycling. Located in cytoplasm. Is expressed in intestine and nervous system. Orthologous to human PLAA (phospholipase A2 activating protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ufd-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (9940753..9944107)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UFD-2 and UFD-3 bind to CDC-48 in a mutually exclusive manner.CDC-48 preferentially interacts with UFD-3 in C. elegans under the physiological condition.
Title: Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C05C10.5 (e-PCR)
- UniSTS:315407

C05C10.6 (e-PCR)
- UniSTS:321186

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin recycling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PUL domain-containing protein;Ubiquitin fusion degradation protein 3 homolog

NP_001254232.1

Confirmed by transcript evidence

NP_496146.1

Confirmed by transcript evidence

NP_496147.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9940753..9944107

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063746.5 → NP_496147.1 Ubiquitin fusion degradation protein 3 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496147.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EFK5

Conserved Domains (5) summary

COG2319
Location:23 → 275

WD40; WD40 repeat [General function prediction only]

pfam08324
Location:587 → 836

PUL; PUL domain

pfam09070
Location:420 → 472

PFU; PFU (PLAA family ubiquitin binding)

sd00039
Location:77 → 115

7WD40; WD40 repeat [structural motif]

cl02567
Location:22 → 318

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_063745.4 → NP_496146.1 Ubiquitin fusion degradation protein 3 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496146.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EES6, G5EFK5

Conserved Domains (4) summary

sd00039
Location:77 → 115

7WD40; WD40 repeat [structural motif]

pfam08324
Location:589 → 838

PUL; PUL domain

pfam09070
Location:422 → 474

PFU; PFU (PLAA family ubiquitin binding)

cl25539
Location:22 → 320

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001267303.3 → NP_001254232.1 PUL domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254232.1

Status: REVIEWED

UniProtKB/TrEMBL

I2HAD6

Conserved Domains (1) summary

pfam08324
Location:4 → 201

PUL; PUL domain