pkc-3 Protein kinase C-like 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pkc-3
Official Full Name: Protein kinase C-like 3
Primary source: WormBase:WBGene00004034
Locus tag: CELE_F09E5.1
See related: AllianceGenome:WB:WBGene00004034
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein domain specific binding activity and protein serine/threonine kinase activity. Involved in several processes, including antifungal innate immune response; gonad development; and response to wounding. Located in apical plasma membrane; cortical actin cytoskeleton; and cytosol. Is expressed in several structures, including D; Psub4; enteric muscle; hypodermis; and pharyngeal-intestinal valve. Orthologous to human PRKCI (protein kinase C iota) and PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pkc-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (5380027..5384169)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A polarity pathway for exocyst-dependent intracellular tube extension.
Title: A polarity pathway for exocyst-dependent intracellular tube extension.
The Role of pkc-3 and Genetic Suppressors in Caenorhabditis elegans Epithelial Cell Junction Formation.
Title: The Role of pkc-3 and Genetic Suppressors in Caenorhabditis elegans Epithelial Cell Junction Formation.
Epidermal PAR-6 and PKC-3 are essential for larval development of C. elegans and organize non-centrosomal microtubules.
Title: Epidermal PAR-6 and PKC-3 are essential for larval development of C. elegans and organize non-centrosomal microtubules.
a circuit consisting of aPKC and the PRBH-domain protein ensures the local recruitment of PAR-1 to a well-defined cortical compartment
Title: Establishment of the PAR-1 cortical gradient by the aPKC-PRBH circuit.
The pkc-3 protein is a possible cooperation and involvement in postembryo lethality, developmental timing, as well as SNARE protein trafficking.
Title: par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans.
Data show that Phospho-LIN-5 co-localizes with PKC-3 at the anterior cell cortex and temporally coincides with a switch from anterior- to posterior-directed spindle movements in the one-cell embryo.
Title: aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division.
Binding to PKC-3, but not to PAR-3 or to a conventional PDZ domain ligand, is required for PAR-6 function in C. elegans
Title: Binding to PKC-3, but not to PAR-3 or to a conventional PDZ domain ligand, is required for PAR-6 function in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F09E5.1 (e-PCR)
- UniSTS:309617

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in antifungal innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gastrulation	IEA Inferred from Electronic Annotation more info
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonadal mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in single fertilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Protein kinase C-like 3

NP_495011.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5380027..5384169

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062610.9 → NP_495011.1 Protein kinase C-like 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495011.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A7VJC8, Q19266

Conserved Domains (4) summary

cd06404
Location:13 → 95

PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...

smart00220
Location:253 → 522

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam00130
Location:128 → 178

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl21453
Location:257 → 586

PKc_like; Protein Kinases, catalytic domain