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    cec-4 Chromo domain-containing protein cec-4 [ Caenorhabditis elegans ]

    Gene ID: 177536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cec-4
    Official Full Name
    Chromo domain-containing protein cec-4
    Primary source
    WormBase:WBGene00017990
    Locus tag
    CELE_F32E10.2
    See related
    AllianceGenome:WB:WBGene00017990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables methylated histone binding activity. Involved in chromosome attachment to the nuclear envelope; regulation of cell differentiation; and regulation of gene expression. Located in nuclear inner membrane. Is expressed in germ cell and somatic cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cec-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (7576181..7577325)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C-type lectin domain-containing protein 180 Neighboring gene ncRNA Neighboring gene Tudor domain-containing protein Neighboring gene Chromo domain-containing protein Neighboring gene NUC153 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone H3K9 methylation promotes formation of genome compartments in Caenorhabditis elegans via chromosome compaction and perinuclear anchoring. Bian Q, et al. Proc Natl Acad Sci U S A, 2020 May 26. PMID 32385148, Free PMC Article
    2. Lamina-Dependent Stretching and Unconventional Chromosome Compartments in Early C. elegans Embryos. Sawh AN, et al. Mol Cell, 2020 Apr 2. PMID 32105612, Free PMC Article
    3. Alternative somatic and germline gene-regulatory strategies during starvation-induced developmental arrest. Webster AK, et al. Cell Rep, 2022 Oct 11. PMID 36223742, Free PMC Article
    4. Mechanism of chromatin segregation to the nuclear periphery in C. elegans embryos. Gonzalez-Sandoval A, et al. Worm, 2016. PMID 27695653, Free PMC Article
    5. Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei. Cabianca DS, et al. Nature, 2019 May. PMID 31118512

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The coupling of the LMN-Y59C mutation with the ablation of CEC-4, a chromodomain protein that anchors H3K9-methylated chromatin at the nuclear envelope (NE), suppressed the muscle-associated disease phenotypes
      Title: Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model.
    2. In a screen for perinuclear anchors of heterochromatin, study identified a previously uncharacterized C. elegans chromodomain protein, CEC-4; CEC-4 binds to mono-, di-, or tri-methylated H3K9 and localizes at the nuclear envelope independently of H3K9 methylation and nuclear lamin.CEC-4 is necessary for heterochromatin anchoring, but not for transcriptional repression.
      Title: Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome attachment to the nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome attachment to the nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome attachment to the nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Chromo domain-containing protein cec-4
    NP_501231.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7576181..7577325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068830.10 → NP_501231.1  Chromo domain-containing protein cec-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501231.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19972
      UniProtKB/TrEMBL
      A0A1B4Z3W4
      Conserved Domains (1) summary
      smart00298
      Location:86 → 140
      CHROMO; Chromatin organization modifier domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19972.1

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