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    tmyb-1 TOM1-like protein 2 [ Caenorhabditis elegans ]

    Gene ID: 180723, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmyb-1
    Official Full Name
    TOM1-like protein 2
    Primary source
    WormBase:WBGene00015561
    Locus tag
    CELE_C07A12.7
    See related
    AllianceGenome:WB:WBGene00015561
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable clathrin binding activity. Predicted to be involved in signal transduction. Predicted to be active in endosome and membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including TOM1L2 (target of myb1 like 2 membrane trafficking protein) and TOM1 (target of myb1 membrane trafficking protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tmyb-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (4517747..4521051, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene putative rho GDP-dissociation inhibitor Neighboring gene Suppressor of presenilin protein 3 Neighboring gene ncRNA Neighboring gene Protein disulfide-isomerase 2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TOM1-like protein 2
    NP_508776.1
    • Confirmed by transcript evidence
    NP_508777.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4517747..4521051 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076376.8 → NP_508777.1  TOM1-like protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95QX5
      Conserved Domains (2) summary
      cd14233
      Location:251 → 336
      GAT_TOM1_like; GAT domain found in target of myb protein 1 (Tom1) protein family
      cd03565
      Location:38 → 176
      VHS_Tom1_like; VHS (Vps27/Hrs/STAM) domain of Tom1 subfamily

    2. NM_076375.6 → NP_508776.1  TOM1-like protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYH5
      Conserved Domains (2) summary
      cd14233
      Location:217 → 302
      GAT_TOM1_like; GAT domain found in target of myb protein 1 (Tom1) protein family
      cd03565
      Location:38 → 176
      VHS_Tom1_like; VHS (Vps27/Hrs/STAM) domain of Tom1 subfamily
    Nucleotide Protein
    Heading Accession and Version

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