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    dbn-1 DreBriN 1/DreBriN-like (where Drebrin is from Developmentally REgulated BRaIN protein) family homolog [ Caenorhabditis elegans ]

    Gene ID: 176813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dbn-1
    Official Full Name
    DreBriN 1/DreBriN-like (where Drebrin is from Developmentally REgulated BRaIN protein) family homolog
    Primary source
    WormBase:WBGene00010664
    Locus tag
    CELE_K08E3.4
    See related
    AllianceGenome:WB:WBGene00010664
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including positive regulation of axon extension; postsynaptic actin cytoskeleton organization; and regulation of actin filament polymerization. Predicted to be located in cell periphery and cytoplasm. Predicted to be active in several cellular components, including lamellipodium; postsynaptic density; and postsynaptic membrane. Predicted to colocalize with actin filament. Orthologous to several human genes including DBNL (drebrin like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dbn-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (13759444..13762069, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene Transducer of Cdc42-dependent actin assembly protein 2 homolog Neighboring gene UTP--glucose-1-phosphate uridylyltransferase Neighboring gene Rac GTPase-activating protein 1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Game of Zones: how actin-binding proteins organize muscle contraction. Butkevich E, et al. Worm, 2016 Apr-Jun. PMID 27383012, Free PMC Article
    2. Drebrin-like protein DBN-1 is a sarcomere component that stabilizes actin filaments during muscle contraction. Butkevich E, et al. Nat Commun, 2015 Jul 6. PMID 26146072
    3. WIP-1 and DBN-1 promote scission of endocytic vesicles by bridging actin and Dynamin-1 in the C. elegans intestine. Shi X, et al. J Cell Sci, 2019 Jun 17. PMID 31118234
    4. ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans. Kreis P, et al. Nat Commun, 2019 Jan 30. PMID 30700723, Free PMC Article
    5. A Caenorhabditis elegans nck-1 and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteins. Sitaram A, et al. PLoS Pathog, 2022 Nov. PMID 36374839, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. that the interaction between DBN-1 and F-actin is essential for Dynamin-1 (DYN-1) recruitment at endocytic sites
      Title: WIP-1 and DBN-1 promote scission of endocytic vesicles by bridging actin and Dynamin-1 in the C. elegans intestine.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of axon extension IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynaptic actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cellular component biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DreBriN 1/DreBriN-like (where Drebrin is from Developmentally REgulated BRaIN protein) family homolog
    NP_499840.1
    • Product from WormBase gene class dbn;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13759444..13762069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067439.7 → NP_499840.1  DreBriN 1/DreBriN-like (where Drebrin is from Developmentally REgulated BRaIN protein) family homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499840.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUT0
      Conserved Domains (2) summary
      cd11281
      Location:3 → 138
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
      cl17036
      Location:589 → 642
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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