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    col-141 Nematode cuticle collagen N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 188515, updated on 9-Dec-2024

    Summary

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    Official Symbol
    col-141
    Official Full Name
    Nematode cuticle collagen N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00000714
    Locus tag
    CELE_T15B7.5
    See related
    AllianceGenome:WB:WBGene00000714
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cuticle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in Bethlem myopathy and Ullrich congenital muscular dystrophy 1B. Orthologous to human COL6A2 (collagen type VI alpha 2 chain). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See col-141 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (6829704..6830739)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Chloride channel CLIC-like protein 1 Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene GRIP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BMP Signaling Determines Body Size via Transcriptional Regulation of Collagen Genes in Caenorhabditis elegans. Madaan U, et al. Genetics, 2018 Dec. PMID 30274988, Free PMC Article
    2. Further Extension of Lifespan by Unc-43/CaMKII and Egl-8/PLCβ Mutations in Germline-Deficient Caenorhabditis elegans. Mack HID, et al. Cells, 2022 Nov 8. PMID 36428956, Free PMC Article
    3. The CHARGE syndrome ortholog CHD-7 regulates TGF-β pathways in Caenorhabditis elegans. Jofré DM, et al. Proc Natl Acad Sci U S A, 2022 Apr 12. PMID 35394881, Free PMC Article
    4. Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression. Halaschek-Wiener J, et al. Genome Res, 2005 May. PMID 15837805, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nematode cuticle collagen N-terminal domain-containing protein
    NP_504735.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6829704..6830739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072334.3 → NP_504735.1  Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504735.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17035
      Conserved Domains (2) summary
      PRK12800
      Location:237 → 287
      fliF; flagellar MS-ring protein; Reviewed
      smart01088
      Location:13 → 64
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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