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    sir-2.3 NAD-dependent protein deacylase sir-2.3 [ Caenorhabditis elegans ]

    Gene ID: 185876, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sir-2.3
    Official Full Name
    NAD-dependent protein deacylase sir-2.3
    Primary source
    WormBase:WBGene00004802
    Locus tag
    CELE_F46G10.3
    See related
    AllianceGenome:WB:WBGene00004802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone deacetylase activity. Predicted to be involved in epigenetic regulation of gene expression. Located in mitochondrion. Is expressed in body wall musculature; head; pharynx; and somatic gonad. Orthologous to human SIRT4 (sirtuin 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sir-2.3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (13332014..13333846)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SEFIR domain-containing protein Neighboring gene NAD-dependent protein deacylase sir-2.2 Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene SSD domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites. Zhang B, et al. Nat Chem Biol, 2024 Jul. PMID 38167917
    2. Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans. Sangaletti R, et al. PLoS Genet, 2017 Aug. PMID 28820880, Free PMC Article
    3. C. elegans sirtuins. Viswanathan M, et al. Methods Mol Biol, 2013. PMID 24014398
    4. Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Wirth M, et al. Mitochondrion, 2013 Nov. PMID 23438705, Free PMC Article
    5. Trilobatin, a Component from Lithocarpus polystachyrus Rehd., Increases Longevity in C. elegans Through Activating SKN1/SIRT3/DAF16 Signaling Pathway. Li N, et al. Front Pharmacol, 2021. PMID 33935768, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD-dependent protein lysine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase activity, NAD-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein lysine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NAD-dependent protein deacylase sir-2.3
    NP_510220.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13332014..13333846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077819.4 → NP_510220.1  NAD-dependent protein deacylase sir-2.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510220.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20481
      Conserved Domains (1) summary
      cd01409
      Location:20 → 284
      SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20481.1

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