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    tef teflon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36920, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tefprovided by FlyBase
    Official Full Name
    teflonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086350
    Locus tag
    Dmel_CG8961
    See related
    AllianceGenome:FB:FBgn0086350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8961; Dmel\CG8961; l(2)k15914
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in male meiosis I and male meiosis chromosome separation. Located in autosome. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tef in Genome Data Viewer
    Location:
    53F2-53F2; 2-81 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17054546..17056835, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12942051..12944340, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing, arthropod-specific, member 6 Neighboring gene uncharacterized protein Neighboring gene fat-spondin Neighboring gene uncharacterized protein Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The teflon gene is required for maintenance of autosomal homolog pairing at meiosis I in male Drosophila melanogaster. Tomkiel JE, et al. Genetics, 2001 Jan. PMID 11139508, Free PMC Article
    2. From early homologue recognition to synaptonemal complex formation. Zickler D. Chromosoma, 2006 Jun. PMID 16570189
    3. Sex Chromosome Pairing Mediated by Euchromatic Homology in Drosophila Male Meiosis. Hylton CA, et al. Genetics, 2020 Mar. PMID 31915134, Free PMC Article
    4. When size does not matter: pairing sites during meiosis. McKim KS. Cell, 2005 Dec 16. PMID 16360029
    5. Uncharted territories: Solving the mysteries of male meiosis in flies. Lee L, et al. PLoS Genet, 2024 Mar. PMID 38489251, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role for Tef as a bridging molecule that holds autosome bivalents together via heterochromatic connections.
      Title: Molecular characterization of teflon, a gene required for meiotic autosome segregation in male Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    teflon
    Names
    CG8961-PA
    lethal (2) k15914
    tef-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17054546..17056835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079042.4 → NP_523766.1  teflon [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523766.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B6UYC2, B6UYC7, B6UYC8, B6UYD0, B6UYD1, B6UYD2, B6UYD3, B6UYD5, B6UYD6, B6UYD8, B6UYE0, B6UYE5, B6UYE6, B6UYE9, B6UYF1, B6UYF2, B6UYF3, Q5MBE0, Q7K4M4
      Related
      FBpp0086165
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K4M4.1 Q7K4M4

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