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    Gnf1 Germ line transcription factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40607, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gnf1provided by FlyBase
    Official Full Name
    Germ line transcription factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004913
    Locus tag
    Dmel_CG1119
    See related
    AllianceGenome:FB:FBgn0004913
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1119; Dmel\CG1119; DmRFC1; dRF-Cp140; dRFC140; Gnf-1; gnf1; GTF-1; gtf1; Gtf1; ONF-CAACAA; RF-C 140; RfC; RFC; rfc1; RFC1; RfC140; RFC140
    Summary
    Enables DNA binding activity. Involved in dendrite morphogenesis. Located in nucleus. Is expressed in several structures, including CNS glial cell; adult head; antennal primordium; central brain primordium; and head epidermis primordium. Human ortholog(s) of this gene implicated in West Nile fever and congenital heart disease. Orthologous to human RFC1 (replication factor C subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gnf1 in Genome Data Viewer
    Location:
    82E2-82E2; 3-47.1 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4906622..4910081)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (732344..735803)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene labial associated factor Neighboring gene long non-coding RNA:CR45580 Neighboring gene Chondrocyte-derived ezrin-like domain containing protein Neighboring gene long non-coding RNA:CR45188

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Electron microscopic analysis reveals that replication factor C is sequestered by single-stranded DNA. Keller RC, et al. Nucleic Acids Res, 1999 Sep 1. PMID 10446230, Free PMC Article
    2. Purification and characterization of an active N-acetylglucosaminyltransferase enzyme complex from Streptococci. Wu R, et al. Appl Environ Microbiol, 2010 Dec. PMID 20971868, Free PMC Article
    3. DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C. Allen BL, et al. Nucleic Acids Res, 1998 Sep 1. PMID 9705493, Free PMC Article
    4. Identification and characterization of Drosophila female germ line transcriptional control elements. Frank LH, et al. Development, 1992 Feb. PMID 1592002
    5. Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. Mossi R, et al. J Biol Chem, 1997 Jan 17. PMID 8999859

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA replication factor C complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of DNA replication factor C complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    germ line transcription factor 1
    Names
    CG1119-PA
    CG1119-PB
    Gnf1-PA
    Gnf1-PB
    Replication-factor-C 140kD subunit
    germline transcription factor
    replication factor C 140kD subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4906622..4910081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014605.3 → NP_001014605.1  germ line transcription factor 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014605.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35600
      Conserved Domains (5) summary
      COG5275
      Location:151 → 358
      COG5275; BRCT domain type II [General function prediction only]
      PRK04195
      Location:421 → 969
      PRK04195; replication factor C large subunit; Provisional
      pfam00004
      Location:506 → 633
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam00533
      Location:232 → 309
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam08519
      Location:764 → 917
      RFC1; Replication factor RFC1 C terminal domain

    2. NM_079505.3 → NP_524229.1  germ line transcription factor 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524229.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02031, P35600, Q8MR76
      Related
      FBpp0078478
      Conserved Domains (6) summary
      COG5275
      Location:151 → 358
      COG5275; BRCT domain type II [General function prediction only]
      PRK04195
      Location:421 → 947
      PRK04195; replication factor C large subunit; Provisional
      pfam00004
      Location:484 → 611
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam00533
      Location:232 → 309
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam08519
      Location:742 → 895
      RFC1; Replication factor RFC1 C terminal domain
      cl19912
      Location:605 → 657
      DNA_pol3_delta; DNA polymerase III, delta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35600.2 P35600

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