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    Edg84A Ecdysone-dependent gene 84A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40818, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Edg84Aprovided by FlyBase
    Official Full Name
    Ecdysone-dependent gene 84Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000552
    Locus tag
    Dmel_CG2345
    See related
    AllianceGenome:FB:FBgn0000552
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00004.8; cc1; CG2345; DM-EDG84; DmelEDG84A; Dmel\CG2345; EDG-84; EDG-84A; Edg84; EDG84; EDG84A
    Summary
    Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in chitin-based extracellular matrix. Predicted to be active in extracellular matrix. Is expressed in epidermis; larval head; and larval thorax. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Edg84A in Genome Data Viewer
    Location:
    84A1-84A1; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6684445..6685157)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2510173..2510855)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene twisted bristles roughened eye Neighboring gene O-6-alkylguanine-DNA alkyltransferase Neighboring gene labial Neighboring gene Ccp84Ag Neighboring gene Ccp84Af

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA. Kooistra R, et al. Nucleic Acids Res, 1999 Apr 15. PMID 10101186, Free PMC Article
    2. 20-Hydroxyecdysone is required for, and negatively regulates, transcription of Drosophila pupal cuticle protein genes. Apple RT, et al. Dev Biol, 1991 Aug. PMID 1713868
    3. Regulation of the EDG84A gene by FTZ-F1 during metamorphosis in Drosophila melanogaster. Murata T, et al. Mol Cell Biol, 1996 Nov. PMID 8887679, Free PMC Article
    4. Isolation and characterization of drosocrystallin, a lens crystallin gene of Drosophila melanogaster. Janssens H, et al. Dev Biol, 1999 Mar 1. PMID 10049575
    5. Anterior epidermis-specific expression of the cuticle gene EDG84A is controlled by many cis-regulatory elements in Drosophila melanogaster. Kayashima Y, et al. Dev Genes Evol, 2005 Nov. PMID 16025347

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DHR3 and betaFTZ-F1 activate the EDG84A gene in a redundant manner. The temporal expression of the EDG84A gene is mainly controlled by betaFTZ-F1 but that the binding of DHR3 is also important.
      Title: The binding of multiple nuclear receptors to a single regulatory region is important for the proper expression of EDG84A in Drosophila melanogaster.
    2. The EDG84A gene encoding pupal cuticle protein is one of the targets of ecdysteroid-inducible transcription factor betaFTZ-F1 and is expressed only in anterior epidermis of the body during mid- to late prepupal period.
      Title: Anterior epidermis-specific expression of the cuticle gene EDG84A is controlled by many cis-regulatory elements in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based larval cuticle ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables structural constituent of pupal chitin-based cuticle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chitin-based extracellular matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ecdysone-dependent gene 84A
    Names
    CG2345-PA
    Edg84A-PA
    cuticle cluster 1
    cuticle-like cluster
    ecdysone-dependent gene-84A-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6684445..6685157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079523.3 → NP_524247.1  Ecdysone-dependent gene 84A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524247.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P27780, Q9VI43
      UniProtKB/TrEMBL
      D0IQB7
      Related
      FBpp0081186
      Conserved Domains (1) summary
      pfam00379
      Location:37 → 89
      Chitin_bind_4; Insect cuticle protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27780.1 P27780

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