nme5 NME/NM23 family member 5 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: nme5provided by Xenbase
Official Full Name: NME/NM23 family member 5provided by Xenbase
Primary source: Xenbase:XB-GENE-951087
See related: Ensembl:ENSXETG00000003825 AllianceGenome:Xenbase:XB-GENE-951087
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: NM23-X5
Summary: Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in cilium movement and negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. Predicted to act upstream of or within ribonucleoside triphosphate biosynthetic process and spermatid differentiation. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human NME5 (NME/NM23 family member 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	3	NC_030679.2 (31446769..31457294, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	3	NC_030679.1 (22237218..22246228, complement)

Chromosome 3 - NC_030679.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cilium movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatid differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: nucleoside diphosphate kinase homolog 5

Names: non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)

NP_001072619.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079151.1 → NP_001072619.1 nucleoside diphosphate kinase homolog 5

See identical proteins and their annotated locations for NP_001072619.1

Status: PROVISIONAL

Source sequence(s)

BC123011

UniProtKB/TrEMBL

F7A8Q9, Q0IHR2

Related

ENSXETP00000008322.4, ENSXETT00000008322.5

Conserved Domains (2) summary

cd04418
Location:13 → 144

NDPk5; Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, ...

pfam05186
Location:160 → 197

Dpy-30; Dpy-30 motif