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    reln reelin [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100192371, updated on 4-Jan-2025

    Summary

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    Official Symbol
    relnprovided by Xenbase
    Official Full Name
    reelinprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-982843
    See related
    Ensembl:ENSXETG00000025681 AllianceGenome:Xenbase:XB-GENE-982843
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Summary
    Predicted to enable lipoprotein particle receptor binding activity; metal ion binding activity; and serine-type peptidase activity. Predicted to act upstream of or within cell adhesion; nervous system development; and proteolysis. Predicted to be located in extracellular region and membrane. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; familial temporal lobe epilepsy 7; and schizophrenia. Orthologous to human RELN (reelin). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See reln in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    65
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (77484332..77743047)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 3 NC_030679.1 (67889975..68150495)

    Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene LHFPL tetraspan subfamily member 3 Neighboring gene uncharacterized LOC116409747 Neighboring gene uncharacterized LOC108646166 Neighboring gene solute carrier family 26 member 5 Neighboring gene proteasome 26S subunit, ATPase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC172539

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    reelin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001137612.1 → NP_001131084.1  reelin

      See identical proteins and their annotated locations for NP_001131084.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168471
      UniProtKB/TrEMBL
      A0A6I8RTW7, B5DDZ8, F6YYF0
      Related
      ENSXETP00000086194.2, ENSXETT00000100375.2
      Conserved Domains (20) summary
      cd10036
      Location:205 → 354
      Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin
      cd10037
      Location:529 → 674
      Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10038
      Location:870 → 1037
      Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10039
      Location:1243 → 1413
      Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10040
      Location:1609 → 1778
      Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10041
      Location:1960 → 2134
      Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10042
      Location:2326 → 2482
      Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10043
      Location:2673 → 2857
      Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10044
      Location:3058 → 3232
      Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cd10045
      Location:711 → 865
      Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10046
      Location:1068 → 1223
      Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10047
      Location:1451 → 1601
      Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10048
      Location:1804 → 1953
      Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10049
      Location:2169 → 2318
      Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10050
      Location:2518 → 2665
      Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10051
      Location:2893 → 3053
      Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10052
      Location:3269 → 3429
      Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cl15240
      Location:424 → 559
      Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins
      cd08544
      Location:51 → 181
      Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
      pfam07974
      Location:2134 → 2163
      EGF_2; EGF-like domain

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      77484332..77743047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031897689.1 → XP_031753549.1  reelin isoform X1

      UniProtKB/TrEMBL
      A0A6I8RTW7, A0A8J1J6R1
      Conserved Domains (22) summary
      cd10036
      Location:205 → 354
      Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin
      cd10037
      Location:529 → 674
      Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10038
      Location:870 → 1037
      Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10039
      Location:1243 → 1413
      Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10040
      Location:1609 → 1778
      Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10041
      Location:1960 → 2134
      Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10042
      Location:2326 → 2482
      Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10043
      Location:2673 → 2857
      Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10044
      Location:3058 → 3236
      Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cd10045
      Location:711 → 865
      Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10046
      Location:1068 → 1223
      Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10047
      Location:1451 → 1601
      Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10048
      Location:1804 → 1953
      Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10049
      Location:2169 → 2318
      Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10050
      Location:2518 → 2665
      Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10051
      Location:2893 → 3053
      Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10052
      Location:3273 → 3433
      Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cl15240
      Location:424 → 559
      Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins
      cd08544
      Location:51 → 181
      Reeler; the N-terminal domain of reelin, F-spondin, and a variety of other proteins
      pfam18720
      Location:3238 → 3266
      EGF_Tenascin; Tenascin EGF domain
      pfam01683
      Location:1410 → 1444
      EB; EB module
      pfam07974
      Location:2140 → 2163
      EGF_2; EGF-like domain

    2. XM_012958659.3 → XP_012814113.2  reelin isoform X2

      UniProtKB/TrEMBL
      A0A6I8RTW7, A0A8J0SHW2
      Conserved Domains (22) summary
      cd10036
      Location:205 → 354
      Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin
      cd10037
      Location:529 → 674
      Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10038
      Location:870 → 1037
      Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10039
      Location:1243 → 1413
      Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10040
      Location:1609 → 1778
      Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10041
      Location:1960 → 2134
      Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10042
      Location:2326 → 2482
      Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10043
      Location:2673 → 2857
      Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10044
      Location:3058 → 3236
      Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cd10045
      Location:711 → 865
      Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10046
      Location:1068 → 1223
      Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10047
      Location:1451 → 1601
      Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10048
      Location:1804 → 1953
      Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10049
      Location:2169 → 2318
      Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10050
      Location:2518 → 2665
      Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10051
      Location:2893 → 3053
      Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10052
      Location:3273 → 3433
      Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cl15240
      Location:424 → 559
      Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins
      cd08544
      Location:51 → 181
      Reeler; the N-terminal domain of reelin, F-spondin, and a variety of other proteins
      pfam18720
      Location:3238 → 3266
      EGF_Tenascin; Tenascin EGF domain
      pfam01683
      Location:1410 → 1444
      EB; EB module
      pfam07974
      Location:2140 → 2163
      EGF_2; EGF-like domain

    3. XM_012958660.3 → XP_012814114.2  reelin isoform X3

      UniProtKB/TrEMBL
      A0A6I8RTW7, A0A803KLF3
      Related
      ENSXETP00000050071.5, ENSXETT00000050071.5
      Conserved Domains (22) summary
      cd10036
      Location:205 → 354
      Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin
      cd10037
      Location:529 → 674
      Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10038
      Location:870 → 1037
      Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10039
      Location:1243 → 1413
      Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10040
      Location:1609 → 1778
      Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10041
      Location:1960 → 2134
      Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10042
      Location:2326 → 2482
      Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10043
      Location:2673 → 2857
      Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10044
      Location:3058 → 3232
      Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cd10045
      Location:711 → 865
      Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10046
      Location:1068 → 1223
      Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10047
      Location:1451 → 1601
      Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10048
      Location:1804 → 1953
      Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10049
      Location:2169 → 2318
      Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10050
      Location:2518 → 2665
      Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10051
      Location:2893 → 3053
      Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10052
      Location:3269 → 3429
      Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cl15240
      Location:424 → 559
      Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins
      cd08544
      Location:51 → 181
      Reeler; the N-terminal domain of reelin, F-spondin, and a variety of other proteins
      pfam18720
      Location:3234 → 3262
      EGF_Tenascin; Tenascin EGF domain
      pfam01683
      Location:1410 → 1444
      EB; EB module
      pfam07974
      Location:2140 → 2163
      EGF_2; EGF-like domain

    4. XM_031897690.1 → XP_031753550.1  reelin isoform X4

      UniProtKB/TrEMBL
      A0A6I8RTW7, A0A8J1J957
      Conserved Domains (22) summary
      cd10036
      Location:205 → 354
      Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin
      cd10037
      Location:529 → 674
      Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10038
      Location:870 → 1037
      Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10039
      Location:1243 → 1413
      Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10040
      Location:1609 → 1778
      Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10041
      Location:1960 → 2134
      Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10042
      Location:2326 → 2482
      Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10043
      Location:2673 → 2857
      Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10044
      Location:3058 → 3231
      Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cd10045
      Location:711 → 865
      Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10046
      Location:1068 → 1223
      Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10047
      Location:1451 → 1601
      Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10048
      Location:1804 → 1953
      Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10049
      Location:2169 → 2318
      Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10050
      Location:2518 → 2665
      Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10051
      Location:2893 → 3053
      Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10052
      Location:3268 → 3428
      Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cl15240
      Location:424 → 559
      Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins
      cd08544
      Location:51 → 181
      Reeler; the N-terminal domain of reelin, F-spondin, and a variety of other proteins
      pfam18720
      Location:3233 → 3261
      EGF_Tenascin; Tenascin EGF domain
      pfam01683
      Location:1410 → 1444
      EB; EB module
      pfam07974
      Location:2140 → 2163
      EGF_2; EGF-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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