dclre1c DNA cross-link repair 1C [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: dclre1cprovided by Xenbase
Official Full Name: DNA cross-link repair 1Cprovided by Xenbase
Primary source: Xenbase:XB-GENE-952753
See related: Ensembl:ENSXETG00000005403 AllianceGenome:Xenbase:XB-GENE-952753
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary: Predicted to enable 5'-3' DNA exonuclease activity and damaged DNA binding activity. Predicted to be involved in double-strand break repair via nonhomologous end joining; interstrand cross-link repair; and telomere maintenance. Predicted to act upstream of or within DNA recombination and DNA repair. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Omenn syndrome; common variable immunodeficiency; severe combined immunodeficiency; and severe combined immunodeficiency with sensitivity to ionizing radiation. Orthologous to human DCLRE1C (DNA cross-link repair 1C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	3	NC_030679.2 (81233750..81248235)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	3	NC_030679.1 (71626449..71640999)

Chromosome 3 - NC_030679.2 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables 5'-3' DNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via nonhomologous end joining	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain