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    GstD6 Glutathione S transferase D6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48339, updated on 19-Dec-2024

    Summary

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    Official Symbol
    GstD6provided by FlyBase
    Official Full Name
    Glutathione S transferase D6provided by FlyBase
    Primary source
    FLYBASE:FBgn0010042
    Locus tag
    Dmel_CG4423
    See related
    AllianceGenome:FB:FBgn0010042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4423; Dmel\CG4423; DmGST25; DmGstd6; DmGSTD6; gst; Gst; GST; Gst D6; Gst-D6; gstD25; GstD25; gstd6; GSTD6
    Summary
    Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstD6 in Genome Data Viewer
    Location:
    87B8-87B8; 3-52 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12377128..12377907)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8202850..8203629)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase D4 Neighboring gene Glutathione S transferase D5 Neighboring gene Glutathione S transferase D7 Neighboring gene Glutathione S transferase D8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia. Jumbo-Lucioni PP, et al. Dis Model Mech, 2013 Jan. PMID 22773758, Free PMC Article
    2. Aniline exposure associated with up-regulated transcriptional responses of three glutathione S-transferase Delta genes in Drosophila melanogaster. Chan WC, et al. Environ Toxicol Pharmacol, 2015 Mar. PMID 25682008
    3. Effects of cadmium on fecundity and defence ability of Drosophila melanogaster. Hu X, et al. Ecotoxicol Environ Saf, 2019 Apr 30. PMID 30665104
    4. The glutathione S-transferase D genes. A divergently organized, intronless gene family in Drosophila melanogaster. Toung YP, et al. J Biol Chem, 1993 May 5. PMID 7683659
    5. Genome-wide transcription analysis of clinal genetic variation in Drosophila. Chen Y, et al. PLoS One, 2012. PMID 22514645, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase D6
    Names
    CG4423-PA
    GstD6-PA
    glutathione S transferase D25
    NP_524915.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12377128..12377907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080176.3 → NP_524915.1  glutathione S transferase D6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524915.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TX93, Q9VG94
      Related
      FBpp0082045
      Conserved Domains (3) summary
      PLN02395
      Location:11 → 208
      PLN02395; glutathione S-transferase
      cd03177
      Location:88 → 204
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      cd03045
      Location:1 → 74
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG94.1 Q9VG94

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