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    metG methionine--tRNA ligase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946643, updated on 3-Dec-2024

    Summary

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    Official Symbol
    metG
    Official Full Name
    methionine--tRNA ligase
    Primary source
    ECOCYC:EG10586
    Locus tag
    b2114
    See related
    ASAP:ABE-0006991
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2107
    Summary
    metG is an essential gene. [More information is available at EcoGene: EG10586]. MetG is a member of the family of aminoacyl tRNA synthetases, which interpret the genetic code by covalently linking amino acids to their specific tRNA molecules. [More information is available at EcoCyc: EG10586].
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    Genomic context

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    Sequence:
    NC_000913.3 (2194300..2196333)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2574 domain-containing protein YehE Neighboring gene P-loop NTPase family protein Mrp Neighboring gene PF05406 family protein YehF Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallographic study at 2.5 A resolution of the interaction of methionyl-tRNA synthetase from Escherichia coli with ATP. Brunie S, et al. J Mol Biol, 1990 Nov 20. PMID 2254937
    2. Regulation of methionyl-transfer ribonucleic acid synthetase formation in Escherichia coli and Salmonella typhimurium. Archibold ER, et al. J Bacteriol, 1973 Jun. PMID 4576394, Free PMC Article
    3. The subunit structure of methionyl-tRNA synthetase from Escherichia coli. Koch GL, et al. FEBS Lett, 1974 Mar 15. PMID 4605346
    4. Molecular cloning and primary structure of the Escherichia coli methionyl-tRNA synthetase gene. Dardel F, et al. J Bacteriol, 1984 Dec. PMID 6094501, Free PMC Article
    5. Methionyl-tRNA synthetase from Escherichia coli. Primary structure of the active crystallised tryptic fragment. Barker DG, et al. Eur J Biochem, 1982 Oct. PMID 6756915

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Methionyl-tRNA synthetase from Escherichia coli. Primary structure of the active crystallised tryptic fragment.
    2. Apo-MetRS structure shows a preference for binding methionine compared with the 19 other natural amino acids.
      Title: Selectivity and specificity of substrate binding in methionyl-tRNA synthetase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methionine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methionyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methionyl-tRNA aminoacylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    methionine--tRNA ligase
    NP_416617.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2194300..2196333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416617.1 methionine--tRNA ligase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416617.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JDZ1
      Conserved Domains (1) summary
      PRK00133
      Location:6 → 677
      metG; methionyl-tRNA synthetase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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