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    ccp cytochrome c peroxidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948038, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ccp
    Official Full Name
    cytochrome c peroxidase
    Primary source
    ECOCYC:EG12244
    Locus tag
    b3518
    See related
    ASAP:ABE-0011493
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3503; yhjA
    Summary
    FNR regulon. [More information is available at EcoGene: EG12244]. A yhjA mutant shows increased sensitivity to exogenous peroxides . [More information is available at EcoCyc: EG12244].
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    Genomic context

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    Sequence:
    NC_000913.3 (3667791..3669188, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator GadX Neighboring gene glutamate decarboxylase A Neighboring gene cytoplasmic trehalase Neighboring gene putative DNA-binding transcriptional regulator YhjB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YhjA - An Escherichia coli trihemic enzyme with quinol peroxidase activity. Nóbrega CS, et al. Biochim Biophys Acta Bioenerg, 2018 Jun. PMID 29550214
    2. Dynamics, hydration, and motional averaging of a loop-gated artificial protein cavity: the W191G mutant of cytochrome c peroxidase in water as revealed by molecular dynamics simulations. Baron R, et al. Biochemistry, 2007 Sep 18. PMID 17718514
    3. The Escherichia coli yhjA gene, encoding a predicted cytochrome c peroxidase, is regulated by FNR and OxyR. Partridge JD, et al. Microbiology (Reading), 2007 May. PMID 17464064
    4. Escherichia coli cytochrome c peroxidase is a respiratory oxidase that enables the use of hydrogen peroxide as a terminal electron acceptor. Khademian M, et al. Proc Natl Acad Sci U S A, 2017 Aug 15. PMID 28696311, Free PMC Article
    5. A reassessment of the FNR regulon and transcriptomic analysis of the effects of nitrate, nitrite, NarXL, and NarQP as Escherichia coli K12 adapts from aerobic to anaerobic growth. Constantinidou C, et al. J Biol Chem, 2006 Feb 24. PMID 16377617

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YhjA is an Escherichia coli trihemic enzyme with quinol peroxidase activity.
      Title: YhjA - An Escherichia coli trihemic enzyme with quinol peroxidase activity.
    2. Data show that cytochrome c peroxidases (Ccp) transcription requires both the presence of H2O2 and the absence of O2.
      Title: Escherichia coli cytochrome c peroxidase is a respiratory oxidase that enables the use of hydrogen peroxide as a terminal electron acceptor.
    3. Here both FNR and OxyR are shown to regulate expression of the E. coli yhjA gene.
      Title: The Escherichia coli yhjA gene, encoding a predicted cytochrome c peroxidase, is regulated by FNR and OxyR.
    4. Five molecular dynamics simulations of the W191G cavity mutant of cytochrome c peroxidase in explicit water reveal distinct dynamic and hydration behavior.
      Title: Dynamics, hydration, and motional averaging of a loop-gated artificial protein cavity: the W191G mutant of cytochrome c peroxidase in water as revealed by molecular dynamics simulations.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    cytochrome c peroxidase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3667791..3669188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417975.1 cytochrome c peroxidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417975.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8R428
      Conserved Domains (2) summary
      COG1858
      Location:125 → 461
      MauG; Cytochrome c peroxidase [Posttranslational modification, protein turnover, chaperones]
      pfam14376
      Location:18 → 153
      Haem_bd; Haem-binding domain
    Nucleotide Protein
    Heading Accession and Version

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