CD14 CD14 molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD14provided by HGNC
Official Full Name: CD14 moleculeprovided by HGNC
Primary source: HGNC:HGNC:1628
See related: Ensembl:ENSG00000170458 MIM:158120; AllianceGenome:HGNC:1628
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment.
Expression: Broad expression in placenta (RPKM 87.5), liver (RPKM 85.2) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q31.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (140631732..140633701, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (141157140..141159109, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (140011317..140013286, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD14 is a decision-maker between Fas-mediated death and inflammation.
Title: CD14 is a decision-maker between Fas-mediated death and inflammation.
Virion-incorporated CD14 enables HIV-1 to bind LPS and initiate TLR4 signaling in immune cells.
Title: Virion-incorporated CD14 enables HIV-1 to bind LPS and initiate TLR4 signaling in immune cells.
Association analysis between CD14 gene polymorphisms and peri-implantitis susceptibility in a Chinese population.
Title: Association analysis between CD14 gene polymorphisms and peri-implantitis susceptibility in a Chinese population.
CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population.
Title: CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population.
Homodimeric Granzyme A Opsonizes Mycobacterium tuberculosis and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14.
Title: Homodimeric Granzyme A Opsonizes Mycobacterium tuberculosis and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14.
Decreased expression of TIGIT on CD14 + monocytes correlates with clinical features and laboratory parameters of patients with primary Sjogren's syndrome.
Title: Decreased expression of TIGIT on CD14 + monocytes correlates with clinical features and laboratory parameters of patients with primary Sjögren's syndrome.
Association of serum CD14 level and functional polymorphism C-159T in the promoter region of CD14 gene with allergic rhinitis.
Title: Association of serum CD14 level and functional polymorphism C-159T in the promoter region of CD14 gene with allergic rhinitis.
Multifaceted role of CD14 in innate immunity and tissue homeostasis.
Title: Multifaceted role of CD14 in innate immunity and tissue homeostasis.
Increased circulating levels of MIP-1alpha and CD14 are associated with the presence of severe stenosis and hypoechoic plaques in patients with carotid atherosclerosis.
Title: Increased circulating levels of MIP-1α and CD14 are associated with the presence of severe stenosis and hypoechoic plaques in patients with carotid atherosclerosis.
The role of CD14 and CSF1R in osteoarthritis and gastritis.
Title: The role of CD14 and CSF1R in osteoarthritis and gastritis.

Submit: New GeneRIF Correction See all GeneRIFs (600)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	CD14 is significantly downregulated from the surface of HIV-1 Nef-expressing THP-1 monocytes compared to that from the surface of control cells	PubMed
	nef	HIV-1 Nef enhances membrane-bound (m) CD14 expression on monocytes but does not induce the release of soluble CD14 into the culture supernatants of PBMC; the upregulation of mCD14 expression does not involve endogenously produced IL-10	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC98826P1 (e-PCR)
- UniSTS:273681

PMC108311P1 (e-PCR)
- UniSTS:270134

RH67904 (e-PCR)
- UniSTS:34631

G62118 (e-PCR)
- UniSTS:139164

RH11569 (e-PCR)
- UniSTS:73130

PMC148872P1 (e-PCR)
- UniSTS:271024

CD14 (e-PCR), detects polymorphism
- UniSTS:181700

RH17946 (e-PCR)
- UniSTS:4037

CD14_82 (e-PCR)
- UniSTS:276172

PMC136845P1 (e-PCR)
- UniSTS:270804

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables lipopolysaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables lipopolysaccharide immune receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables lipoteichoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables opsonin receptor activity	TAS Traceable Author Statement more info	PubMed
enables peptidoglycan immune receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in cell surface pattern recognition receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to diacyl bacterial lipopeptide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to lipoteichoic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to molecule of bacterial origin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to triacyl bacterial lipopeptide	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-8 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of toll-like receptor 4 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in response to electrical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to magnesium ion	IEA Inferred from Electronic Annotation more info
involved_in response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	TAS Traceable Author Statement more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of lipopolysaccharide receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of lipopolysaccharide receptor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: monocyte differentiation antigen CD14

Names: my23 antigen; myeloid cell-specific leucine-rich glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023178.1 RefSeqGene

Range

5527..6970

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000591.4 → NP_000582.1 monocyte differentiation antigen CD14 precursor

See identical proteins and their annotated locations for NP_000582.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-4 encode the same protein.

Source sequence(s)

BC010507, CF593452

Consensus CDS

CCDS4232.1

UniProtKB/Swiss-Prot

P08571, Q53XT5, Q96FR6, Q96L99, Q9UNS3

UniProtKB/TrEMBL

B2R888, F1C4A7

Related

ENSP00000304236.6, ENST00000302014.11

Conserved Domains (2) summary

COG4886
Location:167 → 332

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:196 → 223

LRR_RI; leucine-rich repeat [structural motif]
NM_001040021.3 → NP_001035110.1 monocyte differentiation antigen CD14 precursor

See identical proteins and their annotated locations for NP_001035110.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.

Source sequence(s)

BC010507, DA426297

Consensus CDS

CCDS4232.1

UniProtKB/Swiss-Prot

P08571, Q53XT5, Q96FR6, Q96L99, Q9UNS3

UniProtKB/TrEMBL

B2R888, F1C4A7

Related

ENSP00000426543.2, ENST00000498971.7

Conserved Domains (2) summary

COG4886
Location:167 → 332

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:196 → 223

LRR_RI; leucine-rich repeat [structural motif]
NM_001174104.2 → NP_001167575.1 monocyte differentiation antigen CD14 precursor

See identical proteins and their annotated locations for NP_001167575.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.

Source sequence(s)

BC010507, BP300412, DA426297

Consensus CDS

CCDS4232.1

UniProtKB/Swiss-Prot

P08571, Q53XT5, Q96FR6, Q96L99, Q9UNS3

UniProtKB/TrEMBL

B2R888, F1C4A7

Related

ENSP00000425447.2, ENST00000512545.2

Conserved Domains (2) summary

COG4886
Location:167 → 332

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:196 → 223

LRR_RI; leucine-rich repeat [structural motif]
NM_001174105.2 → NP_001167576.1 monocyte differentiation antigen CD14 precursor

See identical proteins and their annotated locations for NP_001167576.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.

Source sequence(s)

BC010507, DA269805, DA426297

Consensus CDS

CCDS4232.1

UniProtKB/Swiss-Prot

P08571, Q53XT5, Q96FR6, Q96L99, Q9UNS3

UniProtKB/TrEMBL

B2R888, F1C4A7

Related

ENSP00000430884.2, ENST00000519715.2

Conserved Domains (2) summary

COG4886
Location:167 → 332

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:196 → 223

LRR_RI; leucine-rich repeat [structural motif]