kif4a.S kinesin family member 4A S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: kif4a.S
Official Full Name: kinesin family member 4A S homeolog
Primary source: Xenbase:XB-GENE-6079277
Locus tag: XELAEV_18041964mg
See related: EnsemblRapid:ENSXLAG00005025279 AllianceGenome:Xenbase:XB-GENE-6079277
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: kif4; klp1; Xklp1; kif4a; kif4a-a; kif4a.L
Summary: Predicted to enable several functions, including ATP binding activity; microtubule binding activity; and microtubule motor activity. Predicted to act upstream of or within microtubule-based movement; mitotic spindle organization; and spindle elongation. Predicted to be located in several cellular components, including chromosome; microtubule; and nucleus. Predicted to be part of microtubule associated complex. Is expressed in genital system. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 100. Orthologous to human KIF4A (kinesin family member 4A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8S

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8S	NC_054386.1 (49409502..49472345)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8S	NC_030739.1 (48653041..48715824)

Chromosome 8S - NC_054386.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results mechanistically explain how the two conserved, essential midzone proteins PRC1 and Xklp1 cooperate to constitute a minimal protein module capable of dynamically organizing the core structure of the central anaphase spindle.
Title: A minimal midzone protein module controls formation and length of antiparallel microtubule overlaps.
Xklp1 affects microtubule polymerization during M-phase.
Title: Chromokinesin Xklp1 contributes to the regulation of microtubule density and organization during spindle assembly.
Xklp1 could inhibit microtubule growth and shrinkage; Xklp1 could also act as a fast, nonprocessive, plus end-directed molecular motor
Title: A kinesin-like motor inhibits microtubule dynamic instability.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within microtubule-based movement	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chromosome-associated kinesin KIF4

Names: chromokinesin; chromosome-associated kinesin KLP1; kinesin family member 4A L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087550.1 → NP_001081019.1 chromosome-associated kinesin KIF4

See identical proteins and their annotated locations for NP_001081019.1

Status: PROVISIONAL

Source sequence(s)

X82012

UniProtKB/Swiss-Prot

Q91784, Q9PSI0

UniProtKB/TrEMBL

A0A974C379, Q6IRM2

Related

ENSXLAP00005075113.1, ENSXLAT00005076693.1

Conserved Domains (4) summary

smart00129
Location:8 → 344

KISc; Kinesin motor, catalytic domain. ATPase

TIGR04211
Location:337 → 462

SH3_and_anchor; SH3 domain protein

cd01372
Location:7 → 338

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam05033
Location:1068 → 1118

Pre-SET; Pre-SET motif