bet-1 Bromodomain-containing protein bet-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: bet-1
Official Full Name: Bromodomain-containing protein bet-1
Primary source: WormBase:WBGene00022473
Locus tag: CELE_Y119C1B.8
See related: AllianceGenome:WB:WBGene00022473
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables SUMO binding activity and lysine-acetylated histone binding activity. Involved in several processes, including multicellular organismal locomotion; muscle cell cellular homeostasis; and regulation of DNA-templated transcription. Located in chromosome; metaphase plate; and nucleus. Is expressed in several structures, including body wall musculature; hypodermis; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Cornelia de Lange syndrome 6; idiopathic pulmonary fibrosis; lymphoma (multiple); male infertility (multiple); and photosensitivity disease. Orthologous to several human genes including BRD2 (bromodomain containing 2) and BRDT (bromodomain testis associated). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See bet-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 14

Sequence:: Chromosome: I; NC_003279.8 (4525961..4534805, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the C. elegans acetylated-histone-binding protein BET-1 is required for the establishment and maintenance of stable fate in various lineages.
Title: Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans.
BET-1 as a Sumo-dependent attenuator of LET-60-mediated signalling and our characterisation suggests that BET-1 can be sumoylated.
Title: An RNAi-based dimorphic genetic screen identified the double bromodomain protein BET-1 as a sumo-dependent attenuator of RAS-mediated signalling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-124 (e-PCR)
- UniSTS:241609

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables SUMO binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone binding	IEA Inferred from Electronic Annotation more info
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables lysine-acetylated histone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organismal locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in multicellular organismal locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein stability	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in metaphase plate	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Bromodomain-containing protein bet-1

NP_001364495.1

Confirmed by transcript evidence

NP_001366623.1

Confirmed by transcript evidence

NP_001366624.1

Confirmed by transcript evidence

NP_001366625.1

Confirmed by transcript evidence

NP_001366626.1

Confirmed by transcript evidence

NP_001367704.1

Confirmed by transcript evidence

NP_001367705.1

Confirmed by transcript evidence

NP_001379011.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4525961..4534805 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001377574.2 → NP_001364495.1 Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9MQE5

Conserved Domains (6) summary

cd05497
Location:39 → 145

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:262 → 363

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PLN02967
Location:95 → 240

PLN02967; kinase

pfam15791
Location:684 → 730

DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

pfam17035
Location:526 → 592

BET; Bromodomain extra-terminal - transcription regulation

cl21508
Location:371 → 416

Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
NM_001379848.2 → NP_001366626.1 Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9MPT0

Conserved Domains (6) summary

cd05497
Location:39 → 145

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:262 → 363

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PLN02967
Location:95 → 240

PLN02967; kinase

pfam15791
Location:684 → 730

DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

pfam17035
Location:526 → 592

BET; Bromodomain extra-terminal - transcription regulation

cl21508
Location:371 → 416

Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
NM_001379845.1 → NP_001366623.1 Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9MM65

Conserved Domains (6) summary

cd05497
Location:39 → 145

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:262 → 363

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PLN02967
Location:95 → 240

PLN02967; kinase

pfam15791
Location:682 → 728

DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

pfam17035
Location:526 → 592

BET; Bromodomain extra-terminal - transcription regulation

cl21508
Location:371 → 416

Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
NM_001379837.2 → NP_001367704.1 Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (6) summary

cd05497
Location:39 → 145

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:262 → 363

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PLN02967
Location:95 → 240

PLN02967; kinase

pfam15791
Location:680 → 726

DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

pfam17035
Location:526 → 592

BET; Bromodomain extra-terminal - transcription regulation

cl21508
Location:371 → 416

Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
NM_001379846.3 → NP_001366624.1 Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9MN31

Conserved Domains (6) summary

cd05497
Location:39 → 145

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:262 → 363

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PLN02967
Location:95 → 240

PLN02967; kinase

pfam15791
Location:682 → 728

DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

pfam17035
Location:526 → 592

BET; Bromodomain extra-terminal - transcription regulation

cl21508
Location:371 → 416

Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
NM_001379840.2 → NP_001367705.1 Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

H2KZI7, Q95Y80

Conserved Domains (6) summary

cd05497
Location:39 → 145

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:262 → 363

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PLN02967
Location:95 → 240

PLN02967; kinase

pfam15791
Location:680 → 726

DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

pfam17035
Location:526 → 592

BET; Bromodomain extra-terminal - transcription regulation

cl21508
Location:371 → 416

Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
NM_001392164.1 → NP_001379011.1 Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9MMD4

Conserved Domains (6) summary

cd05497
Location:39 → 145

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:262 → 363

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PLN02967
Location:95 → 240

PLN02967; kinase

pfam15791
Location:682 → 728

DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

pfam17035
Location:526 → 592

BET; Bromodomain extra-terminal - transcription regulation

cl21508
Location:371 → 416

Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...
NM_001379843.2 → NP_001366625.1 Bromodomain-containing protein bet-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9MMP9

Conserved Domains (6) summary

cd05497
Location:39 → 145

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:262 → 363

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PLN02967
Location:95 → 240

PLN02967; kinase

pfam15791
Location:682 → 728

DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

pfam17035
Location:526 → 592

BET; Bromodomain extra-terminal - transcription regulation

cl21508
Location:371 → 416

Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...