insc-1 Protein inscuteable homologue C-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: insc-1
Official Full Name: Protein inscuteable homologue C-terminal domain-containing protein
Primary source: WormBase:WBGene00018392
Locus tag: CELE_F43E2.3
See related: AllianceGenome:WB:WBGene00018392
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cytoskeletal anchor activity. Predicted to be involved in apical protein localization; establishment of mitotic spindle orientation; and regulation of asymmetric cell division. Predicted to be active in apical cortex. Is expressed in several structures, including body wall musculature; hypodermis; pharynx; and tail. Orthologous to human INSC (INSC spindle orientation adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See insc-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 16

Sequence:: Chromosome: II; NC_003280.10 (7358893..7363247)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F43E2.3 (e-PCR)
- UniSTS:310300

F43E2.9 (e-PCR)
- UniSTS:315766

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cytoskeletal anchor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apical protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in asymmetric cell division	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of asymmetric cell division	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in apical cortex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Protein inscuteable homologue C-terminal domain-containing protein

NP_001367460.1

Confirmed by transcript evidence

NP_001368642.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7358893..7363247

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381496.3 → NP_001367460.1 Protein inscuteable homologue C-terminal domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O02088
NM_001381495.1 → NP_001368642.1 Protein inscuteable homologue C-terminal domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1T5HUK5