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    ced-7 ABC transporter ced-7;ABC transporter domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176352, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ced-7
    Official Full Name
    ABC transporter ced-7;ABC transporter domain-containing protein
    Primary source
    WormBase:WBGene00000421
    Locus tag
    CELE_C48B4.4
    See related
    AllianceGenome:WB:WBGene00000421
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and lipid transporter activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and phospholipid efflux. Located in plasma membrane. Is expressed in Z2; Z3; germ line; neuronal sheath cell; and pharyngeal-intestinal valve. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ced-7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    16
    Sequence:
    Chromosome: III; NC_003281.10 (9570390..9580089, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Secreted protein Neighboring gene Uncharacterized protein Neighboring gene putative acyl-coenzyme A oxidase acox-1.5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transbilayer phospholipid movement and the clearance of apoptotic cells. Williamson P, et al. Biochim Biophys Acta, 2002 Dec 30. PMID 12531537
    2. Immunopathological consequences of the loss of engulfment genes: the case of ABCA1. Grau GE, et al. J Soc Biol, 2005. PMID 16471259
    3. C. elegans secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment. Zhang Y, et al. Curr Biol, 2012 Jul 24. PMID 22727700
    4. let-7 miRNA controls CED-7 homotypic adhesion and EFF-1-mediated axonal self-fusion to restore touch sensation following injury. Basu A, et al. Proc Natl Acad Sci U S A, 2017 Nov 21. PMID 29109254, Free PMC Article
    5. Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms. Li Z, et al. PLoS Genet, 2015 Jun. PMID 26061275, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. let-7 miRNA inhibits functional restoration via EFF-1-mediated axonal self-fusion by reducing ced-7 expression.
      Title: let-7 miRNA controls CED-7 homotypic adhesion and EFF-1-mediated axonal self-fusion to restore touch sensation following injury.
    2. The results reveal the existence of a WLDS/Nmnat-independent axonal degeneration pathway in C. elegans, conservation of the axonal clearance machinery, and a function for CED-7 and NRF-5 in this process.
      Title: The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons.
    3. CED-7 and TTR-52 may promote the efflux of phosphatidylserine (PS) from apoptotic cells through the generation of extracellular PS vesicles, which lead to exoplasmic leaflet (exPS) expression on phagocytes via TTR-52 and CED-1 to facilitate cell corpse clearance.
      Title: CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells.
    4. Review. CED-7 is akey player in engulfment. Its mode of action is unusual in the panorama of engulfment receptors since they act as lipid transporters. Loss of CED-7 has phenotypic consequences exclusively on engulfment.
      Title: Immunopathological consequences of the loss of engulfment genes: the case of ABCA1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ATPase-coupled transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process involved in development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in apoptotic process involved in development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in engulfment of apoptotic cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in left/right axis specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phospholipid efflux IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process involved in development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process involved in development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of distal tip cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of engulfment of apoptotic cell IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of engulfment of apoptotic cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ABC transporter ced-7;ABC transporter domain-containing protein
    NP_001021225.1
    • Partially confirmed by transcript evidence
    NP_001255012.1
    • Partially confirmed by transcript evidence
    NP_001366984.1
    • Partially confirmed by transcript evidence
    NP_499115.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9570390..9580089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026054.4 → NP_001021225.1  ABC transporter ced-7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021225.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34358
      Conserved Domains (4) summary
      cd03263
      Location:1366 → 1578
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:533 → 818
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:947 → 1312
      ABC2_membrane_3; ABC-2 family transporter protein
      pfam12730
      Location:1087 → 1281
      ABC2_membrane_4; ABC-2 family transporter protein

    2. NM_066714.5 → NP_499115.2  ABC transporter ced-7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499115.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34358
      Conserved Domains (4) summary
      cd03263
      Location:1364 → 1576
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:533 → 818
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:947 → 1310
      ABC2_membrane_3; ABC-2 family transporter protein
      pfam12730
      Location:1085 → 1279
      ABC2_membrane_4; ABC-2 family transporter protein

    3. NM_001268083.3 → NP_001255012.1  ABC transporter domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255012.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0P274
      Conserved Domains (4) summary
      cd03263
      Location:1433 → 1645
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:600 → 885
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:1014 → 1379
      ABC2_membrane_3; ABC-2 family transporter protein
      pfam12730
      Location:1154 → 1348
      ABC2_membrane_4; ABC-2 family transporter protein

    4. NM_001379863.2 → NP_001366984.1  ABC transporter ced-7 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76287, P34358, P34359
      Conserved Domains (1) summary
      TIGR01257
      Location:152 → 1693
      rim_protein; retinal-specific rim ABC transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34358.6

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